摘要
双侧下丘注射NE或阿托品后,大鼠听源性癫痫发作(audiogenic seizure, AS)显著减弱。注射NE前5分钟,先在双侧下丘注射α_2-NE能受体阻断剂盐酸育亨宾(4μg),1小时后,NE对AS的抑制作用被完全逆转,而未预先注射育亨宾的大鼠的AS易感性仍显著低下。双侧下丘注射毒蕈碱样受体的激动剂毛果芸香碱(10μg)后,AS易感品系中不发作的大鼠表现出AS易感性。 实验结果提示:下丘NE水平的提高减弱AS,NE可能是作用于下丘内与外周α_2-NE能受体相似的受体而抑制AS的。下丘毒蕈碱样受体的激活对AS起促进作用。
The severity of audiogenic seizures was reduced by injection of NE or atro-pine into bilateral inferior colliculi. One hour after the injection of NE, the inhibitory effect of NE was reversed by bilateral injection of alpha-2 adrener-gic receptor antagonist yohimbine into the inferior colliculi 5 minutes before the injection of NE, however the severity of audiogsnic seizures of the control rats was still reduced significantly. Audiogenic seizure-nonsusceptible rats of the P77-PMC strain exhibited audiogenic seizure susceptibility by bilateral injection of muscarinic receptor agonist pilocarpine into the inferior colliculi.The results suggest: The elevation of the level of NE in the inferior colliculi reduces the severity of audiogenic seizures, the inhibitory effect of NE on audiogenic seizures is attributable to an action on a receptor similar to the peripheral alpha-2 adrenergic receptor. Activation of the muscarinic receptors in the inferior colliculi facilitates audiogenic seizures.
出处
《基础医学与临床》
CSCD
1990年第6期52-55,共4页
Basic and Clinical Medicine
基金
国家自然科学基金
关键词
下丘
癫痫
去甲肾上腺素
听源性
inferior colliculi audiogenic seizure NE pilocarpine rat
