摘要
目的探索抗精神病药物对心电图的影响。方法对1277例住院精神疾病患者服用抗精神病药后ECG变化进行分析,以性别、年龄、不同药物种类进行比较,并对多个危险因素进行Logistic回归分析。结果749例（58.7%）住院患者ECG异常,其中窦性心动过速最常见。26~35岁年龄段ECG异常发生的比例（46.7%）最小。服用氯氮平的患者出现ECG异常的比率最高（69.1%）。年龄作为唯一与心电图异常相关的变量进入了Logistic回归模型。结论抗精神病药物引起ECG异常较常见。用药期间,特别是对老年患者应注意定期检查ECG。
Objective： To analyse the electrocardiogram （ECG） changes in patients with antipsychotics. Methods： The ECG of 1277 inpatients with antipsyehotics were collected and the factors of sex, age and kinds of antipsychotics were compared and muhivariable logistic regression analysis was included. Results：There were 749（58.7% ） inpatients with abnormal ECG,in which sinus tachycardia was the most common abnormal change. The abnormal rate was lower inpatients between age 26 -35 （46.7%）. The patients with clozapine had high incidence of abnornaml EEG rate （69.1% ）. Logistic regression analysis showed that the only variable of age entered the predictive equation. Conclusion：The ECG changes are common in patients wth antipsychotics. It warrants that patients with antipsychootics should accept ECG examination routinly , especially for those elderly patients.
出处
《上海精神医学》
2008年第6期348-351,共4页
Shanghai Archives of Psychiatry
