摘要
目的观察骨恶性纤维组织细胞瘤(MFH-B)采用皮下埋植式动脉化疗泵的治疗效果。方法2004年4月～2008年5月共治疗5例骨恶性纤维组织细胞瘤患者,发病部位髂骨1例,股骨3例,胫骨1例;术前经皮下埋植式给药装置(化疗泵)行表阿霉素、顺铂导向性灌注3～5次,联合咖啡因或去甲斑蝥素治疗,化疗后通过临床及影像学观察有明显改变后进行保肢手术。结果4例患者化疗后疼痛完全缓解,1例明显缓解,且病变均有明显影像学改变,术后病理显示5例均有中重度的化疗反应,平均随访26个月,肺转移1例死亡,其余4例无复发和转移。结论皮下埋植式动脉化疗治疗MFH-B具有良好效果,化疗后的影像学改变显著,化疗后的肿瘤细胞广泛坏死,病理改变明显。
Objective To investigate the effect of subcutaneously embedded chemotherapy pump for malignant fibrous histiocytoma of bone （MFH-B）. Methods From 2004. April to 2008. May, five patients with MFH-B were treated. The tumor location was the ilium （n=1）, the femor （n=1） and the tibia （n=1）. Adriamycin and Cisplatin were perfused with subcutaneously embedded chemotherapy pump 3 to 5 times, combined with caffeine and Norcantharidin, The therapeutic effect was evaluated by clinical and radiological changes, followed by limb-saving operation. Results Four patients had total pain relief and 1 patient had pain relieved after chemotherapy. The radiological changes were obvious. All patients had chemotherapy reaction of medium to severe level. The mean follow-up was 26 months. One patient died of lung metastases, and the other 4 survived without recurrence. Conclusions Implantable intra-arterial induction chemotherapy is effective for MFH-B. The radiological changes were obvious, with abroad cell necrosis after this chemotherapy strategy.
出处
《中国骨肿瘤骨病》
2008年第6期335-338,共4页
Chinse Journal Of Bone Tumor And Bone Disease
