摘要
目的比较精神应激与生理应激对SD大鼠焦虑行为的不同影响。方法,采用旁观电击大鼠应激模型作为精神应激模型,以旷场实验、高架十字迷宫实验评估精神应激大鼠与生理应激大鼠的焦虑行为。结果在旷场实验中,外周格数、中央格数、以及修饰数均是生理应激组[分别是(21.60±22.99)个、(4.20±3.26)个、(5.80±2.35)次]低于精神应激组[分别是(47.60±20.87)个、(6.00±3.43)个、(7.00±2.69)次],精神应激组低于正常对照组[分别是(55.80±14.54)个、(7.00±3.47)个、(13.40±5.01)次],差异具有显著性;在高架十字迷宫实验中,开放臂次数以及开放臂时间也是生理应激组最低,精神应激组居中,正常对照组最高,差异具有显著性。结论在旁观电击大鼠应激模型中,生理应激大鼠的焦虑水平较精神应激大鼠明显。
Objective To compare the effects of mental stress and physical stress on the anxiety behavior in SD rats. Methods 24 male SD rats were allocated into mental stress group, physiological stress group and control group randomly, and the Communication Box was applied to establish animal model of mental stress, then assessed their anxiety behavior through the Open field test and elevated plus maze test. Results In the Open field test, the numbers of squares crossed peripherally and centrally, and the grooming frequency significantly lowered in physiological stress group and in mental stress group compared with that in control group, and were significantly higher in mental stress group than in physiological stress group. The elevated plus maze test demonstrated similar results in the numbers of open arm entries and the time spent in open arms among these three groups. Conclusion In Communication Box model, the anxiety behavior level of physiological stress rats were higher than that in mental stress rats.
出处
《中国行为医学科学》
CSCD
2008年第12期1067-1068,共2页
Chinese Journal of Behavioral Medical Science
关键词
精神应激
生理应激
焦虑
行为
大鼠
Mental stress
Physiological stress
Anxiety
Behavior
Rat