摘要
目的探讨阿托伐他汀联合二甲双胍对高血压合并代谢综合征患者血压的影响。方法将选取的高血压患者分为4组,A、B两组为单纯高血压组,C、D两组为高血压合并代谢综合征组,A、C两组服用左旋氨氯地平2.5mg.d-1,B、D两组服用替米沙坦80mg.d-1,治疗4周后测24h动态血压;第5周起C、D两组加服阿托伐他汀10mg.d-1及二甲双胍0.5g.d-1共12周,第12周末测定各组24h动态血压。结果单独使用氨氯地平或替米沙坦后单纯高血压组与高血压合并代谢综合征组的血压降幅比较差异有显著性(P<0.05),加用阿托伐他汀及二甲双胍后高血压合并代谢综合征患者组的血压降幅与单独使用降压药时比较差异有显著性(P<0.05)。结论单独使用降压药物后,单纯高血压组比高血压合并代谢综合征组的降压疗效好;加用阿托伐他汀及二甲双胍后高血压合并代谢综合征组的血压有明显改善,二者联合使用对高血压合并代谢综合征患者有良好的降压效应。
Objective： To study the effects of atorvastatin combined with metformin on blood pressure of hypertensive patients with metabolic syndrome. Method： The selected patients with hypertension were divided into four groups, A, B belonged to the groups of simple hypertension , C, D belonged to the ones of hypertension with metabolic syndrome, A, C took L - amlodipine 2. 5g·d^-1 , B, D took telmisartan 80mg·d^-1 Ambulatory blood pressure were measured after 4 weeks＇ treatment, C, D took atorvastatin 10mg·d^-1 and metformin 0. 5mg·d^-1 in addition from the 5th week for 12 weeks and 24 h ambulatory blood pressure was tested in each group at the end of the 12th week. Results： After individual use of amlodipine or telmisartan, in the blood pressure droping, simply hypertesion group compared with hypertession group with metabolic syndrome, there were significant differences （P 〈 0.05）. The plus use of atorvastatin and metformin than the use of only antihypertensive drugs in hypertession group with metabolic syndrome, blood pressure droping produced significant differences （ P 〈 0.05 ）. Conclusions： The antihypertensive effect is better in the groups of simple hypertension than those of hypertension with metabolic syndrome. After having taken atorvastatin and metformin, the blood pressure of the groups of hypertension with metabolic syndrome improves a lot. The antihypertensive effect is excellent after they are taken by the patients with atorvastatin combined with metformin.
出处
《湖北中医学院学报》
2008年第4期40-41,共2页
Journal of Hubei College of Traditional Chinese Medicine
