摘要
目的探讨少枝胶质细胞肿瘤AEG-1的表达，及其与肿瘤恶性程度和预后的关系。方法回顾性复习42例经病理证实的少枝胶质细胞肿瘤患者的病史资料，随访患者的预后，采用免疫组织化学法检测42例肿瘤标本和4例正常脑组织AEG-1表达。结果AEG-1总阳性率为45．2％（19／42），OG（WHOⅡ）组和AOG（WHOⅢ）组的表达率分别为35．5％（11／31）和72．7％（8／11）（Х^2=4．55，P〈0．05），表达水平与肿瘤的级别呈正相关（r=0．392，P〈0．05），4例正常脑组织中均无AEG-1表达。42例患者中，失访率14．3％（6例），AEG-1（-），（＋）和（＋＋）组中位生存期分别为7．6、2．3、1．6年（Х^2=32．74，P〈0．01），表明AEG-1的表达水平与少枝胶质细胞肿瘤患者的生存时间呈负相关（r=-0．876，P〈0．01）。结论AEG-1可能是少枝胶质细胞肿瘤恶性程度的分子标志物之一，可作为临床评估预后的潜在指标之一。
Objective To investigate the expression of AEG-1 in oligodendrogliomas and the relevance of AEG-1 with tumor malignant degree and prognosis. Methods This was a retrospective review of 42 cases of oligodendrogliomas. Patients＇ records were retrieved by hospital notes as well as outpatient follow up records. AEG-1 expression levels in 42 human oligodendrogliomas and 4 normal brain tissue samples were detected by the EnVision immunohistochemical staining. Results Nineteen of 42 brain tumors （45.2%） expressed AEG-1. The expression rate in OG （WHO Ⅱ） and AOG （WHO Ⅲ） groups was 35.5 % （ 11/31 ） and 72.7 % （8/11 ） respectively （Х^2 = 4.55,0.01 〈 P 〈 0.05 ）, and the expression level was positively correlate with the tumor malignant degree （ r = 0. 392,0.01 〈 P 〈 0.05 ）. Of all 42 cases of oligodendrogliomas,14.3% （6 cases） lost to follow up. The median survival time in AEG-1 （ - ）, （ ＋ ） and （ ＋＋ ）groups was 7.6,2.3 and 1.6 years respectively （Х^2 = 32.74,P 〈0.01 ）. Log-rank test and Kaplan-Meier curves anylasis indicated the expession of AEG-1 had a significantly negative correlation with survival time （ r = - 0. 876,P 〈 0.01 ）. Conclusion It is suggested that AEG-1 is one of molecular markers associated with malignant degree of oligodendrogliomas, and one of indexes in juding the progonosis of patients.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2008年第12期1633-1634,共2页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金资助项目（30770763）
广东省自然科学基金资助项目（06021228）
