摘要
目的探讨胸腔积液患者血清和胸水中癌胚抗原(CEA)、CYFRA21-1、神经元特异性烯醇化酶(NSE)的含量变化、对肺癌引起的胸腔积液诊断的临床意义及比较。方法肺癌组和对照组患者共62例,分别测量其血清和胸水中的CEA、CYFRA21-1、NSE的含量,并进行比较。结果肺癌组患者血清和胸水肿瘤标志物均明显高于对照组(P<0.05)。在肺癌组中,胸水CEA、CYFRA21-1均明显高于血清组(均P<0.005),而胸水和血清NSE比较差异无统计学意义(P>0.05)。对照组中胸水和血清各项指标比较差异无统计学无意义(P>0.05)。结论肺癌引起的胸腔积液肿瘤标志物检测胸水的阳性率要高于血清;而临床上联合检测肿瘤标志物对于肺癌诊断的意义更大。
Objective To explore the change of quantities and clinic significance of CEA, CYFRA21- 1, NSE in serum and pleural effusions of patients with malignant pleural effusions caused by lung cancer. Methods 62 cases were divided into two groups ; lung cancer group and pneumonia group; investigator measured and compared quantities of CEA, CYFRA21-1, NSE in serum and pleural effusions. Results In lung cancer group tumor markers in serum and pleural effusions were obviously higher than pneumonia group （ P 〈 O. 05 ）. In lung cancer group, quantities of CEA and CYFRA21-1 in pleural effusions were obviously higher than those in serum （P 〈 0. 005 ） , it was no significance for quantities of NSE in pleural and serum effusions （P 〉 0. 05 ）. In pneumonia group, it was no significance for quantities of CEA ,CYFRA21-1, NSE in pleural and serum effusions （P 〉 0. 05 ）. Conclusion In malignant pleural effusions caused by lung cancer, the positive rate of tumor markers in pleural effusions was higher than that in serum; for the clinic work, there was great significance in diagnosis of lung cancer by measuring tumor markers in combining pleural effusions and serum.
出处
《中国实用医药》
2008年第36期59-60,共2页
China Practical Medicine
