摘要
目的回顾分析慢性阻塞性肺疾病(COPD)急性加重期痰细菌培养结果、耐药情况以及与肺功能的关系,为本地区选择抗菌药物提供借鉴。方法在2005年2月至2008年2月期间,收治的慢性阻塞性肺疾病急性加重期患者中随机抽取116例,其中76例痰培养结果阳性,对其进行回顾性分析。结果76例痰培养结果阳性者中有革兰阴性细菌51例(67.11%),革兰阳性细菌18例(23.68%)。真菌7例(9.21%)。细菌感染前4位依次是:铜绿假单胞菌11株(14.47%)、大肠杆菌9株(11.84%)、鲍曼不动杆菌7株(9.21%)及表皮葡萄球菌7株(9.21%)。真菌感染为白色念珠菌。药敏试验显示前5种细菌对哌拉西林、环丙沙星、头孢哌酮等常用抗生素有较高的耐药率。COPD患者随着肺功能损害的加重常伴随假单胞菌、肠杆菌、不动杆菌的高检出率。结论对COPD急性加重期患者,呼吸道感染以革兰阴性细菌为主,痰细菌学培养结果与患者肺功能损害关系密切。
Objective To retrospective analyze the sputum bacteria culture result, resistance and the relation with pulmonary function of chronic obstructive pulmonary disease （COPD） during acute exacerbation stage,and offer suggestion for anti - bacteria drug selection in the local region. Methods From February 2005 to February 2008, 116 patients who has been given therapy due to COPD in acute exacerbation stage were randomly selected, among whom 76 cases showed positive result in sputum bacteria culture. And we analyzed retrospectively on them. Results In these 76 cases of sputum bacteria cuhure positive patients, 51 cases were affected by gram - negative bacteria （67. 11% ）, 18 cases by gram- positive bacteria （23.68%）, and 7 cases by fungi （9.21%）. The most common four types bacteria affection were： 11 strains of Pseudomonas aeruginosa （14.47%） , 9 strains of Escherichia coli （11.84%）, 7 strains of Acinetobacter baumannii （9. 21% ） and 7 strains of Staphylococcus epidermidis （9.21%）. The fungi affection was Candida albicans. The drug sensitive test showed that the first five types of bacteria had high resistance to regular antibiotics such as piperacillin, ciprofloxacin, cefoperazone. In COPD patients, with the exacerbation of pulmonary function being damaged, Pseudomonas aeruginosa, Enterrobacter and Acinetobacter had high detection rate. Conclusion For the patients in acute exacerbation stage of COPD, respiratory tract infection was mainly caused by gram - negative bacteria, the result of sputum bacteria culture had close relationship with the pulmonary function damage of patient.
出处
《医学研究杂志》
2008年第12期94-96,共3页
Journal of Medical Research
关键词
肺疾病
阻塞性
细菌
耐药
肺功能
Pulmonary disease
Obstructive
Bacteria
Resistance
Pulmonary function
