摘要
目的观察低分子肝素钠对原发性肾病综合征(PNS)患者血浆白介素-8(IL-8)的影响。方法PNS患者56例,其中低分子肝素钠治疗组(肝素组)30例,基础治疗组(基础组)26例,两组治疗前及治疗后第7天、第14天采用酶联免疫法测定血浆IL-8水平。设38例健康对照组作比较。结果PNS患者血浆IL-8水平明显高于健康对照组(P<0.01);肝素组治疗7天后血浆IL-8开始下降,但与治疗前比较差异无显著性(P>0.05),治疗14天后下降明显(P<0.01);基础组治疗前后血浆IL-8差异无显著性(P>0.05)。结论细胞因子异常参与PNS的发病过程,予低分子肝素钠治疗可以影响患者血浆中IL-8的水平,减轻PNS的肾损伤。
Objective To evaluate the effects of low molecular weight heparin （LMWH） on serum interleukin -8 （IL-8） in patients with primary nephrotic syndrome（PNS）. Methods Of 56 patients with PNS, 30 cases received conventional therapy plus LMWH （heparin group）, 26 cases received conventional therapy alone （conventional group）. An ELISA technique was used to measure the plasma levels of IL- 8 before and on days 7 and 14 after drug administration. 38 healthy individuals were chosen as control group. Results Plasma levels of IL- 8 in patients with PNS were significantly higher than those in healthy group （ P 〈 0.01）. Plasma level of IL- 8 in heparin group began to decrease on day 7 after treatment, but it did not differ from pre-drug administration （ P 〉0.05）,it decreased significantly on day 14 after treatment （ P 〈0.01）. There was no statistical difference in plasma level for conventional group before and after drug administration （ P 〉0.05）. Conclusion Abnormal cytokine may be involved in the development of PNS. LMWH may down - regulate plasma levels of IL- 8 and lessen PNS - induced nephritic injury.
出处
《右江民族医学院学报》
2008年第6期948-949,共2页
Journal of Youjiang Medical University for Nationalities
关键词
低分子肝素钠
肾病综合征
白细胞介素-8
low molecular weight heparin
primary nephritic syndrome
interleukin- 8
