摘要
缺氧诱导因子-1(HIF-1)是缺氧条件下广泛存在于哺乳动物和人体内的一种转录因子,通过上调一些与血管新生和糖酵解有关的基因来介导组织细胞对缺氧的适应,是一种重要的缺氧应答调控因子,其生物学效应由HIF-1亚基实现。HIF-1在维持氧稳定、细胞能量代谢、肿瘤血管形成、细胞增殖与凋亡等很多方面都起着重要作用。本文就HIF-1的生物学特性,HIF-1在血液肿瘤发生发展中的作用及其对预后的影响等研究进展作一综述。
Hypoxia-inducible factor 1 （ HIF-1 ） is a transcription factor in the body of mammalian and human when the environment is short of oxygen , mediating the accommodation of histiocyte cell to hypoxia by up-regulating some gene. It is an important regulation factor reacting to oxygen poor, and its biological effects are implemented by HIF-1 subunit. HIF-1 plays an important functions in keeping stabilization of oxygen, cell energy metabolism, the vasifaction of tumor, cell proliferation and apotosis. This article discussed the biological characteristics of HIF-1 , and its roles in formation, development and prognostic effection in hematologic neoplasms.
出处
《中国现代药物应用》
2008年第24期187-188,共2页
Chinese Journal of Modern Drug Application
关键词
缺氧诱导因子-1
血液肿瘤
血管生成
细胞增殖与凋亡
Hypoxia-inducible factor 1
Hematologic neoplasms
Angiogenesis
Cell proliferation and apotosis
