摘要
目的:探讨肢体韧带样瘤的临床病理特点与治疗。方法:对我院自1994年至2007年所收治的肢体韧带样瘤74例的临床资料进行回顾性分析。结果:男性26例,女性48例,中位年龄33岁(13-69岁)。均为单发病灶,表现为肢体缓慢长大的质地硬韧的软组织肿块。初治47例,复发再治27例。肿块大小2cm×3cm-16cm×46cm。20例位于上肢,54例位于下肢。诊断全部经术后病理证实。33例仅接受手术治疗,41例接受手术联合放疗。术后所有病例获随访,中位随访期为47月(7-146月)。术后肿瘤复发率:单纯手术治疗为36.4,而手术联合放疗为14.6,差异显著(P=0.03)。结论:肢体韧带样瘤表现为缓慢长大、质地硬韧的肌肉内病灶,其治疗应尽可能采取手术切除联合术后放疗,以达到控制肿瘤和保留肢体功能的目标。
Objective：To investigate the clinicopathologic features and optimal treatment of extremity desmoid tumors. Methods：The records of 74 patients with extremity desmoid tumor treated at our hospital between 1994 and 2007 were reviewed. Results ：There were 26 males and 48 females,with a median age of 33 years （range,from 13 to 69 years）. All cases manifested as solitary disease with a slow growing finn soft -tissue mass in an extremity,47 cases presented with primary disease,whereas 27 cases had a recurrent tumor. The tumors,which ranged from 2 cm ×3 cm to 16 cm ×46 cm in size,were located in the upper （n = 20） and the lower （n = 54） extremity. In each case,the di- agnosis was confirmed by an excisional biopsy. 33 cases underwent resection only, the remainder received resection followed by adjuvant radiation with a mean does of 55 cGy. The median follow - up for all cases was 47 months （range, from 7 to 146 months）. Compared with 36.4 % for the patients treated with resection alone, the patients trea- ted with combined resection and radiotherapy had a lower relapse rate of 14.6 % （P = 0.03 ）. Conclusion： Extremity desmoid tumors, which manifests as a slow growing finn lesion in a muscle, should be treated with resection combined postoperative radiotherapy as much as possible to achieve disease control and functional limb preservation.
出处
《现代肿瘤医学》
CAS
2008年第12期2183-2185,共3页
Journal of Modern Oncology
关键词
韧带样瘤
肢体
诊断
治疗
desmoid tumor
extremity
diagnosis
treatment
