摘要
目的观察肝素、低分子肝素治疗不稳定心绞痛疗效。方法将57例不稳定心绞痛患者分为3组:肝素治疗组,低分子肝素治疗组及对照组。根据临床症状及心电图改变评价疗效。观察出血、皮疹等不良反应。根据临床观察终点事件的发生概率判断近期预后。结果肝素治疗组、低分子肝素治疗组及对照组总有效率分别为66.67%、95.65%和25%;终点事件发生率分别为5.56%、4.35%和50%;不良反应率分别为27.78%、8.70%和0。结论肝素、低分子肝素治疗不稳定心绞痛疗效明确,并能有效改善预后。但低分子肝素安全性较高且用法简便,易于临床推广。
Objective To observe the efficacy and side effects of heparin sodium and low molecular weight heparin for unstable angina. Methods Fifty-seven patients with unstable angina were randomly divided into heparin sodium（SH） group, low molecular weight heparin（ LMWH） group and the control group. In addition of general treatments. SH group were given 50ml 0.9% sodium chloride ＋ SH 2ml intravenous injection by micro pump once per day for 7d,and LMWH group were given abdominal subcutaneous injection of LMWH 0,4ml twice per day for 7d. Observe the marked efficiency rates, total efficiency rates,acute infarction rates and untoward reaction rates. Results In SH group, LMWH group and , the control group, the total efficiency rates were respectively 66.67 % vs 95.65 % vs 25 % ; acute infarction rates were respectively 5.56% vs 4.35% vs 50% ;the untoward reaction rates were respectively 27.78% vs 8.70% vs 0. Conclusion Low molecular weight heparin is a safe and effective drug for the patients with unstable angina.
出处
《四川医学》
CAS
2008年第11期1490-1491,共2页
Sichuan Medical Journal
关键词
冠心病
不稳定心绞痛
肝素
低分子肝素
coronary heart disease
unstable angina
heparln
low-molecular-weight heparin
