摘要
信号转导与转录激活因子（signal transducers and activators of transcription，STAT）是一类参与基因转录调控，诱导细胞因子活化的蛋白质家族，可随着细胞因子受体间的相互作用，通过酪氨酸系统的JAK家族而被磷酸化，进而启动特异性基因转录和表达。其中STAT6是惟一能对IL-4受体活性的转录进行信号转导的STAT蛋白，在气道炎症和气道高反应性的发生和发展中起到了重要的作用。
Signal transducers and activators of transcription（STAT） proteins are a recently identified class of transcription factors responsible for mediating many cytokine-induced responses. These proteins become phosphorylated by the Janus kinase family of tyrosine kinases following cytokine-receptor interactions to regulate gene transcription. Of the presently known STAT proteins,only STAT6 is activated in response to the cytokine interleukin-4, and plays an important role in the development, progression of asthma. This suggests that it is necessary to investigate the relationship between STAT6 and asthma
出处
《国际呼吸杂志》
2008年第21期1310-1312,共3页
International Journal of Respiration
关键词
信号转导与转录激活因子6
支气管哮喘
白介素4
Signal transducer and activator of transcription factor 6
Bronchial asthma
Interleukin-4
