摘要
神经干细胞是一种具有自我更新能力的多潜能分化细胞,在神经损伤后,脑室下区和海马齿回颗粒下层的神经干细胞能够增殖,在细胞因子和其他蛋白质的作用下,增殖的干细胞可能会靶向性迁移到损伤区,分化成神经元或神经胶质细胞修复和替代坏死或凋亡的神经元。在迁移过程中,炎症因子、生长因子、趋化因子等通过一系列信号转导途径引导干细胞的迁移,但迁移的因子之间、因子与细胞之间关系网络复杂,受多种因子综合作用的影响,因此目前对内源性神经干细胞的靶向性迁移机制尚不清楚。
Neural stem cells are a kind of self-renewal cells thai have the function of multipotential differentiation. When the brain is injured, the neural stem cells in subventricular zone（SVZ） and subgranual zone（SGZ） of dentate gyrus can proliferate and migrate targetely to injured region to replace the necrosis or apoptosis neurons under the guiding of cytokines and proteins. During the process of migration, various kinds of factors, like inflammatory factors,growth factors and chemotactic factors, contol and regulate the migration of neural stem cells via a series of signal transduction pathway. However, the relationship between the factors and cells is complicated, the mechanisms that endogenous neural stem cells targetely migrate to injured region are not clear. This review focuses on the progerss of recent research on migration mechanism of endogenous neural stem cell in the brain injury and degenerative disease.
出处
《解剖科学进展》
CAS
2008年第4期441-444,448,共5页
Progress of Anatomical Sciences
