摘要
目的比较分析rhG-CSF和MSCs移植对梗死心肌的修复作用,并分析其可能作用机制。方法选择纯种大白兔45只(死亡10只),分为rhG-CSF组(n=12)、MSCs移植组(n=10)和对照组(n=13),于心肌梗死后30d,分别检测其心功能、梗死心肌的形态学以及新生毛细血管密度。结果与对照组相比,rhG-CSF组和MSCs移植左心室收缩末期内径、舒张末期内径明显降低,心功能提高,室壁厚度增加,心肌梗死面积缩小,而梗死区和梗死边缘区新生毛细血管密度增加,具有统计学意义。结论rhG-CSF应用和MSCs移植治疗兔心肌梗死,可明显改善心功能,缩小梗死面积,增加梗死心肌新生毛细血管密度。
Objection To investigate the effect of rhG-CSF and the transplantation of MSCs on myocardial infarction and its possible mechanism. Methods Forty-five rabbits （ten dead） were divided randomly into three groups,including rhG-CSF group（12 cases）, the transplantation of MSCs group（10 cases） and control group（13 cases）. Cardiac function, morphology and capillary density were determined on 30d of post-infarction. Results There was obviously difference in LVDs, LVDd, EF,infarct size, ventricle wall thickness and capillary density in the rhG-CSF group and the transplantation of MSCs group compared with the control group. Conclusion rhG-CSF and the transplantation of MSCs can promote cardiac function,reduce the infarct size and increase the capillary density in myocardial infarction.
出处
《重庆医学》
CAS
CSCD
2008年第23期2667-2669,共3页
Chongqing medicine
基金
贵州省省长基金资助项目(C301)。
