摘要
通过动物及细胞实验研究蚕蛹蛋白多肽液的抗肿瘤作用。蚕蛹蛋白多肽质量浓度增加可使两肿瘤细胞存活率降低;肿瘤细胞总蛋白质含量随多肽浓度的增加逐渐降低(p<0.01),且在0.5～1.5g/L内呈剂量依赖性;对A549和Ketr-3的周期阻滞分别为G2～M期和G0～G1期;蚕蛹蛋白多肽液在150～600mg/g内,对小鼠S180和H22的抑瘤率分别达到28.72%～58.18%和27.64%～63.88%,明显延长EAC小鼠的生存时间。实验结果表明蚕蛹蛋白多肽液有显著的抗肿瘤作用。
According to the results of this study, the inhibition effects of silkworm pupa protein polypetides to on A549 and Kerr-3 cells proliferation are directly proportional to the polypeptides concentration in the range of 0.5 to 1.5 g/L. The polypetides cause a significant G2～M, G0～G1 phase arrest in A549 and Kerr-3 cells respectively. With the dosage of 150 to 600 mg/kg, the polypeptides inhibit sarcinoma 180 by 28.72% to 58.18% and hepatocarcinoma 22 by 27.64% to 63.88%, and significantly prolong the life span of the EAC-bearing mice. As a conclusion, the silkworm supa protein polypeptides has significant anti-tumor effects.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2008年第11期588-590,共3页
Food Science
基金
吉林省教育厅2007年计划资助项目[吉教科合字(2007)第415]
关键词
蚕蛹蛋白
多肽
抗肿瘤
silkworm pupa protein
polypeptides
anti-tumor
