摘要
目的检测胃癌及癌前期病变胃癌单克隆抗体ＭＧ７、癌胚抗原（ＣＥＡ）的表达，以寻找胃癌早期诊断的有效途径。方法采用免疫组化ＡＢＣ法测定１２例正常胃粘膜标本、３２例癌前病变及４２例胃腺癌的ＭＧ７和ＣＥＡ的表达。结果正常胃粘膜无ＭＧ７和ＣＥＡ的表达。结论ＭＧ７和ＣＥＡ和异常表达可作为胃癌发生过程中生物学行为的早期指标。
Objective The expression of MG7 and carcinoembryonic antigen(CEA)in precancer lession and carcinoma of the stomach was investigated in search of an effective mode for early diagnosis of stomach cancer. Method The expression of MG7 and CEA was studied in 12 specimens of normal stomach mucosa,32 precancer lessions and 42 adenocarcinomas of the stomach using ABC immunohistochemical technique.Result No expression of MG7 and CEA was found in normal stomach mucosa.In precancer lesions MG7 positive rate was 25%,CEA 37.5%;in adenocarcinoma MG7 69%,CEA 85.7%.Conclusion Abnormal expression of MG7 and CEA are the early biological marks in gastric carcinogenesis.
出处
《铁道医学》
1997年第6期341-342,I008,共2页
Railway Medical Journal
关键词
胃肿瘤
单克隆抗体
癌胚抗原
癌前病变
MG7
CEA
tissues of gastric carcinoma
gastric mucosa
immunohistochemistry
