摘要
目的:观察特异性免疫治疗(SIT)对慢性变应性荨麻疹的疗效。方法:对慢性特发性荨麻疹患者在临床、病史评估的基础上,进行皮肤点刺试验(SPT)、血清特异性IgE(sIgE)抗体检测(unicap法)及自体血清皮肤试验(ASST)。对病程在半年以上、尘螨SPT阳性且sIgE抗体≥2级、ASST阴性的262例患者,在给予抗组胺药物基础治疗的同时,采用长效尘螨变应原制剂进行SIT治疗。在SIT治疗开始时、0.5年及1年时分别进行临床疗效评估和血清sIgE检测。结果:SIT后大多数患者自觉症状明显改善,血清屋尘螨sIgE抗体明显降低。0.5年时随访221例有效,41例无效(有效率为84.35%),1年时随访243例有效,19例无效(有效率为92.74%)。结论:特异性免疫治疗对屋尘螨抗体阳性的慢性变态反应性荨麻疹有良效。
Objective： To evaluate the clinical effect of specific immunotherapy （SIT） with standardized house dust mite vaccine on chronic urticaria. Methods： On the basis of evaluation of clinical history, patients with chronic urticaria were screened by skin prick test SPT）, serum level of soluble IgE （sIgE） against house dust mite （unicap method） and autologous serum skin test （ASST）. Two hundred and sixty-two patients who had an allergy to house dust mite and with positive history beyond half one year and negative ASST, were given specific immnunotherapy with house dust mite along with antihistaminics. Evaluation of clinical symptoms and detection of serum IgE were performed in half one year, one year after SIT. Results： Clinical and immunological improvement were observed in 221 patients （84.35%） and 243 patients （92.74%）at half one year and one year after SIT, respectively. After SIT, the level of serum specific sIgE decreased significantly. Conclusions： Specific immunotherapy with standardized house dust mite vaccine could significantly improve symptoms and reduce the recurrence rate in patients with chronic urticaria with positive IgE directed to house dust mite.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2008年第12期809-811,共3页
Journal of Clinical Dermatology
基金
第三军医大学西南医院临床研究基金资助项目(SWH2005A020)
关键词
荨麻疹
慢性
变态反应
免疫治疗
特异性
屋尘螨
urticaria, chronic
allergy
immunotherapy, specific
house dust mite
