摘要
目的:探讨吉林地区汉族人群乙型肝炎肝硬化患病与白细胞抗原(HLA)DRB1区等位基因多态性的关联性。方法:采用PCR-SSP方法对吉林地区汉族61例慢性乙型肝炎,44例乙型肝炎肝硬化患者,32名HBV感染自然恢复者及50名健康献血员作对照进行了HLA-DRB1等位基因分型比较。结果:慢性乙型肝炎组HLA-DRB1*1201-3等位基因表达频率为17.21%,明显高于正常对照组8.00%(P=0.0427,RR=2.391);慢性乙型肝炎组与乙型肝炎肝硬化组HLA-DRB1*0701等位基因频率分别为11.48%,12.50%,明显高于正常对照组2.00%(P=0.0066,RR=6.35;P=0.0046,RR=7.00)及HBV感染自然恢复组1.56%(P=0.0183,RR=8.17;P=0.0136,RR=9.00);而所检测HLA-DRB1座位的其它等位基因表达频率在四组间无显著性差异(P>0.05)。结论:吉林地区汉族人群慢性乙型肝炎患病与HLA-DRB1*1201-3、HLA-DRB1*0701等位基因型相关联;而乙型肝炎肝硬化患病仅与HLA-DRB1*0701等位基因型相关联。
Objective：To investigate the association of human leucocyte antigen-DRB1 alleles with chronic hepatitis B and hepatic cirrhosis in Han population of Jilin area. Methods： HLA-DRB1 alleles in 61 patients with chronic hepatitis B, 44 patients with hepatic cirrhosis, 32 spontaneous rehabilitees after HBV infectin, and 50 healthy controls were analyzed by using polymerase chain reaction/sequence specific primer technique.Results：The frequency of HLA-DRB1＊1201-3 allele in chronic hepatitis B group was higher than that in healthy control group （17.21% vs. 8.00%, P = 0. 0427, RR = 2. 391）. The frequency of HLA-DRB1＊0701 allele in chronic hepatitis B group and hepatic cirrhosis group was markedly higher than that in healthy controls group（11.48 % vs.2.00% ,P =0.006 6,RR =6.35;12.50% vs.2.00%, P=0.0046, RR = 7.00） and in spontaneous rehabilitee group （ 11.48 % vs. 1.56 %, P =0.0183, RR = 8.17; 12.50% vs. 1.56 %, P = 0.0136, RR=9.00）. No significant differences frequencies of the other HLA-DRB1 alleles were observed among the four groups. Conclusion： Alleles of HLA-DRB1＊1201-3 and HLA-DRB1＊0701 are closely associated with chronic hepatitis B and maybe susceptible genes or hnkage genes of chronic hepatitis B. HLA-DRB1＊0701 is also closely associated with hepatic cirrhosis and maybe a susceptible gene or linkage gene-posthep-atitis B-cirrhosis in Han population of Jilin area.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2008年第11期1038-1041,共4页
Chinese Journal of Immunology
基金
吉林省科技厅基金资助项目(No.20060416-4)
关键词
肝炎病毒
乙型
肝炎肝硬化
等位基因
人类白细胞抗原
PCR-SSP
Hepatitis B virus
Hepatitis
Hepatic cirrhosis
Alleles
Human leukocyte antigen
Polymerase chain reaction/sequencespecific primer
