摘要
电离辐射生物效应与辐射剂量和剂量率有关，大、中剂量照射以损伤效应为主，低剂量照射可诱导机体的兴奋效应、适应性反应、超敏感性、旁效应等。低剂量全身照射通过诱导免疫增强效应、超敏感性、激活抗氧化酶系统及肿瘤细胞凋亡等机制具有抗肿瘤作用，降低随后较大剂量辐射诱发的肿瘤发生率。目前，低剂量照射在肿瘤防治中的应用正成为研究的热点。
The biological effects of ionizing irradiation is related with dose and dose-rate. Medium to large dose irradiation can induce damaging effect to biosystem, but low dose radiation may induce adaptive response, hormesis, hyper-sensitiveness and bystander effect. Especially experimental data suggest that the antitumor effects of immune enhancement, intrinsic hypersensitivity, activation antioxidase enzymatic system and induction of apoptosis is produced by low-dose total body irradiation. Furthermore it can decrease relative cancer risk in exposed populations. Therefore, the antitumor effect by low-dose irradiation is being widely investigated and intensively researched.
出处
《国际放射医学核医学杂志》
2008年第4期243-246,共4页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金资助项目（30770916）
关键词
辐射剂量
全身照射
辐射耐受性
细胞凋亡
肿瘤治疗方案
Radiation dosage
Whole-body irradiation
Radiation tolerance
Apoptosis
Antineoplatic protocols
