摘要
目的:探讨常规行糖化血红蛋白A1(HBA1c)检测对治疗复发性外阴阴道假丝酵母菌病(RVVC)的指导价值。方法:将符合RVVC诊断标准的病人65例作为实验组,对照组60例为真菌学阴性的健康体检者及复发性细菌性阴道病(RBV)患者,对所有入选者行空腹及餐后2h血糖、血HBA1c检测并计算体重指数。将HBA1c≥5%的58例RVVC患者随机分为2组,试验1组进行糖代谢调整及抗真菌等综合治疗,试验2组仅抗真菌治疗,治愈后1年内复查HBA1c。结果:实验组HBA1c≥5%58例,占89.2%(58/65),而对照组仅5例,占8.3%(5/60),两组间差异非常显著(P<0.001)。实验组HBA1c、体重指数、空腹血糖均高于对照组,两组间差异非常显著(P<0.001);餐后2h血糖实验组较对照组高,但两组间无显著性差异(P>0.05)。HBA1c≥5%的RVVC患者治愈后1年内的复发率,试验1组2例复发(6.7%),试验2组有14例复发(48.28%),两组间差异显著(P<0.01);1年后试验1组与2组HBA1c≥5%的分别为3例(10.3%)与24例(82.8%),两组间差异非常显著(P<0.001)。结论:复发性外阴阴道假丝酵母菌病的非糖尿病患者,存在糖代谢异常。对复发性外阴阴道假丝酵母菌病的患者进行HBA1c检测对指导临床治疗有一定的价值。
Objective： To access the value of plasma concentration of glycosylated hemoglobin A1c（HBA1c） test routine in treatment of women with recurrent vnlvovaginal eandidiasis （RVVC） . Methods： A case -control study of 65 otherwise healthy women who were diagnosed RVVC according to diagnostic criteria and 60 mycology - negative control subjects, half of whom were healty without infections and half had recurrent bacterial vaginosis （BV）. A1l of whom were undergoing test of fasting glucose, glucose at 2 hours after breakfast and plasma concentration of glycosylated hemoglobin A1c as well as the body mass index were counted. The study - group 58 cases whose HBA1e concentration ≥5% were divided into 2 groups. The study - group 1 were treated with anti - fungus combined with glucose - metabolism - modification therapy. The study - group 2 were only treated with anti - fungus within 1 year after curing, all of these subjects were tested HBA1c again. Results： The proportion of HBA1c ≥5% in study - group was significantly higher than that of control - group （89% vs 8.3%, P 〈 0. 001 ）. Women with RVVC had a significantly greater mean in HBA1c, body mass index and fasting glucose, respectively （ P 〈 0. 001 ）. The level of blood sugar after 2 hours food of the study - group was higher than that of the control, but there were no significant difference between the two groups （ P 〉 0. 05 ）. The incidence of RVVC within 1 year after curing was lower in study - group 1 than that in study - group 2, 2 recurrent cases in study - group 1 and 14 in group 2 （6. 7% vs 48.28%, P 〈 0. 01 ）, the proportion of HBA1c ≥5% was lower in study - group 1 than that in study - group 2 （ 10. 3% vs 82. 8%, P 〈0. 001 ） . Conclusion： The nondiabetie women with RV- VC has glucose metabolism abnormality. To test the plasma concentration of glycosylated hemoglobin A1c in women with RWC is of value and which can guide clinical treatment.
出处
《中国妇幼保健》
CAS
北大核心
2008年第32期4547-4549,共3页
Maternal and Child Health Care of China
基金
广西壮族自治区科学技术厅立项课题(项目编号桂科基:0575107)
关键词
复发性外阴阴道假丝酵母菌病
糖化血红蛋白
空腹血糖
体重指数
Recurrent vulvovaginal candidiasis （RVVC）
Glyeosylated hemoglobin A1c （HBA1c）
Fasting glucose
Body mass index （BMI）
