摘要
目的探讨宫颈环形切除术(LEEP)诊治宫颈上皮内瘤变(CIN)的价值。方法回顾性分析LEEP患者561例资料。结果LEEP和阴道镜下多点活检的病理结果完全符合348例(62.0%),升级121例(21.6%);CIN患者LEEP一次性治愈503例(94.0%),LEEP术后再行子宫切除术68例,术后病灶残存33例;LEEP术前高危型人乳头瘤病毒(HR-HPV)负荷量(≥300RLU/PC)对病灶残存的预测有统计学意义(P<0.05)。结论LEEP是诊治CIN的有效手段;LEEP术前HR-HPV负荷量高低对预测术后病灶残存有临床意义。
Objective To evaluate the clinical significance of loop eleetrosurgieal excision procedure （LEEP） in diagnosis and treatment of cervical intraepithelial neoplasia（CIN）. Methods The clinical data of 561 patients underwent LEEP were retrospectively analyzed. Results Of 561 cases,the pathologic diagnosis of LEEP and eolposcopie multiple biopsies was accordant in 348 eases （62.0%） ,and the graded cases were 121（21.6%）. The primary cure was achieved in 503（94.0%） CIN patients. After LEEP, hysterectomy was performed in 68 cases with residual diseases in 34 cases. Pre-cone HR-HPV load [≥300 relative light units （RLU）/positive control （PC）] was a significant predictive factor associated with residual disease （P〈0.05）. Conclusion LEEP is an effective manner of diagnosis and treatment of CIN. Pre-cone HR-HPV load is a significant factor in predicting post-cone residual disease.
出处
《江苏医药》
CAS
CSCD
北大核心
2008年第11期1108-1110,共3页
Jiangsu Medical Journal
关键词
宫颈环形切除术
宫颈上皮内瘤变
Loop electrosurgical excision procedure
Cervical intraepithelial neoptasia
