摘要
[目的]研究孕妇人群中HBV的携带率及HBV携带孕妇的新生儿HBV宫内感染率,分析HBV宫内感染的危险因素。[方法]将HBV携带孕妇作为目标人群;在孕妇产后采集新生儿脐带血检测HBV标志物,发生HBV宫内感染的新生儿作为病例组,未发生的作为对照组,分析HBV宫内感染的危险因素。[结果]2002～2004,共检测了3415名孕妇,HBV携带率为3.34%(114/3415),城镇孕妇HBV携带率(2.91%)低于农村孕妇(5.62%)(χ2=9.23,P﹤0.01);除2例死胎外,在112名HBV携带孕妇所生的112名新生儿中,有33名新生儿发生了HBV宫内感染,感染率为29.46%;多因素分析显示,孕妇HBeAg阳性(OR=3.1495%CI:1.23～8.04)、阴道流血史(OR=4.4795%CI:1.18～16.99)与HBV宫内感染有关联。[结论]合肥地区孕妇HBV携带率较低,且城镇低于农村;孕妇HBeAg阳性、孕期阴道流血史可能是HBV宫内感染的危险因素。
[Objective] To explore the hepatitis B virus （HBV） carrying rate among pregnant women and HBV intrauterine infection rate in neonates of pregnant women with HBV, and to analyze the risk factors of HBV intrauterine infection. [ Methods] pregnant women with HBV were screened as the target population. After delivery, umbilical bloods of neonates were tested. Neonates with HBV by intrauterine infection were selected as cases, while the rest as controls, so as to analyze the risk factors of intrauterine infection. [ Results] A total of 3415 pregnant women were tested in Hefei city from 2002 to 2004, and HBV carrying rate was 3.34% （114/3415） . The carrying rate of HBV in urban pregnant women （2.91%） was significantly lower than rural pregnant wome （5.62%）（x2 = 9.23. P 〈 0.01 ）. 33 of 112 neonates were infected with HBV （29.46%）. Multivariate unconditional logistics regression analysis indicated that the positive of HBeAg （OR=3.14, 95%CI： 1.23-8.04）, history of vagina bleeding （OR=4.47, 95%CI： 1.18-16.99） were correlated with HBV intrauterine infection. [ Conclusion] HBV carrying rate showed to be low among the pregnant women in Hefei. The HBV carrying rate of urban pregnant women was significantly lower than rural pregnant women. Positive maternal HBeAg and history of vagina bleeding may be the risk factors of HBV intrauterine infection.
出处
《现代预防医学》
CAS
北大核心
2008年第22期4366-4368,共3页
Modern Preventive Medicine
关键词
肝炎病毒
乙型
宫内感染
危险因素
Hepatitis virus, B type
Intrauterine infection
Risk factor
