摘要
目的:评价氢质子磁共振波谱(1HMRS)对颅内常见肿瘤的诊断和鉴别诊断价值。方法:对经手术和病理证实的38例脑肿瘤(星形细胞瘤20例,脑膜瘤10例,转移瘤8例)患者行常规MRI和1HMRS扫描,采用软件包FuncTool进行分析,分别计算出肿瘤增强区和对侧正常区的N-乙酰天门冬氨酸(NAA)/胆碱(Cho)、NAA/肌酐(Cr)和Cho/Cr比值。结果:转移瘤、脑膜瘤均有NAA峰,峰值明显低于星形细胞瘤,转移瘤及脑膜瘤NAA/Cho和NAA/Cr比值与星形细胞瘤比较差异有统计学意义(P<0.05);转移瘤与脑膜瘤Cr峰较低或缺乏,星形细胞瘤Cr峰明显下降与正常各占50%;脑膜瘤Cho/Cr显著升高;星形细胞瘤Ⅰ～Ⅱ级与Ⅲ级～Ⅳ级的NAA/Cho、NAA/Cr和Cho/Cr比值差异有统计学意义(P<0.05)。结论:1HMRS可无创地分析脑肿瘤的代谢状况,对脑肿瘤的诊断、鉴别诊断均有较大的价值。
Objective： To study the value of proton MR spectroscopy （1HMRS） in the diagnosis and differential diagnosis of common brain tumors. Methods：Routine MR and proton MR spectroscopy were performed in 20 cases of astrocytoma, 10 cases of meningioma and 8 cases of metastases, who were proven surgically, pathologically and clinically. N-acetylaspartate/Choline （NAA/Cho）, NAA/creatine （Cr） and Cho/Cr ratios were calculated and analyzed by Functool software. Results： Metastases and meningiomashowed lower NAA. NAA/Cho and NAA/Cr of meningioma and metastases were significantly lower （P 〈 0. 05） than astrocytomas. Cr peak of meningioma and metastases decreased or disappeared. Cho/Cr of meningioma was significantly higher than those of other tumors. Significant difference between low-grade （gradeⅠ-Ⅱ） and high-grade （gradeⅢ-Ⅳ） astrocytomas was found in NAA/Cho, NAA/Cr and Cho/Cr ratios（P 〈 0.05）. Conclusion：l HMRS can be used as a supplementary non-traumatic method to analyze the metabolism of brain tumors and is very helpful in their diagnosis and differential diagnosis.
出处
《临床误诊误治》
2008年第11期11-13,共3页
Clinical Misdiagnosis & Mistherapy
关键词
脑肿瘤
质子
磁共振渡谱检查
Brain tumor
Proton
Magnetic resonance spectroscopy
