摘要
目的:探讨抑郁症患者认知功能的损害特点及高压氧联合帕罗西汀治疗对抑郁症患者认知功能的疗效。方法:将92例抑郁症患者随机分为研究组和对照组各46例,两组均首先进行帕罗西汀抗抑郁治疗2周后,研究组给予高压氧治疗,对照组继续单一使用帕罗西汀抗抑郁治疗,共治疗12周。采用HAMD、MMSE、词汇流畅测验、联想学习、数字广度测验、相似、领悟及副反应量表,于治疗前、治疗后第2、4、8、12周末分别对两组进行评定。结果:研究组治疗第12周后MMSE、词汇流畅测验、联想学习测验、数字广度测验与对照组比较差异有显著性(P<0.05);两组HAMD在治疗第2、4、8、12周末分别与治疗前比较差异均有极显著性(P<0.01)。结论:抑郁症患者认知功能损害与病情严重程度和患者特质有关,高压氧治疗可改善抑郁症特质性认知功能损害,提高患者的社会适应能力。
Objective： To explore the characteristics of the harm of cognitive function of the patients with depressive disorder and the efficacy of hyperbaric oxygenation combined with Paroxetine. Methods ： Ninety two patients with depressive disorder were randomly divided into study group and control group （ 46 patients in each group）. Anti - depression medication with Paroxetic was given to the patients in both groups for 2 weeks, afterwards hyperbaric oxygenation was applied in study group and single medication with Paroxetine was continuously used in control group. The course of treatment last 12 weeks and the evaluation was respectively made on the patients in both groups in fluency of commanding vocabulary, ability and scope of calculation and apperception by adopting HAMD and MMSE in the 2nd, 4th ,8th and 12th week before and after treatment. Results： There were significant differences in the comparison of the evaluated aspects in the 12th week between the two groups （ P 〈0. 05 ） ; the significant differences was also found in the comparison of HAMD in 2nd,4th, 8th and 12th week between the two groups comparing with that before treatment （ P 〈 0.01 ）. Conclusion： The harm of cognitive function of the patients with depressive disorder has something to do with the magnitude of severity of depression and patient ＇ s personality. Hyperbaric oxygenation can improve patient＇ s condition and increase their adaptability to society.
出处
《齐鲁护理杂志》
2008年第11期9-11,共3页
Journal of Qilu Nursing
关键词
高压氧
抑郁症
认知功能
Hyperbaric oxygenation
Depression
Cognitive function
