摘要
目的:探讨高危型HPV负荷量与宫颈癌及其前期病变的关系。方法:对2005年1月至2006年12月于本院行宫颈癌筛查的1221例患者临床资料进行统计分析,观察高危型HPV负荷量和宫颈癌及其前期病变的关系,并用ROC曲线分析,确定HC-Ⅱ法检测高危型HPV-DNA判断宫颈病变≥CINⅡ理想的RLU/CO界值。结果:1221例患者组织学诊断为慢性宫颈粘膜炎667例,CIN407例(其中CINⅠ109例、CINⅡ～Ⅲ298例),宫颈癌147例。慢性宫颈炎、CINⅠ、CINⅡ～Ⅲ和宫颈癌患者高危HPV-DNA负荷量的中位数分别为32.58,58.16,103.83和173.68。根据ROC曲线,统计结果中各可能切点的灵敏度和特异度,发现确定预测≥CINⅡ宫颈病变最佳RLU/CO值为3.155,该点灵敏度88%,特异度57%,Youden指数0.446。结论:高危型HPV负荷量与宫颈癌及其前期病变存在明显相关性,预测≥CINⅡ宫颈病变高危HPV负荷量最佳值为3.155。
Objective：To determine the association between high-risk type human papillomavirus （HR-HPV） load and cervical carcinoma and precancerous lesions. Methods： 1221 patients who came to screen for cervical carcinoma were observed. Their clinical data was analyzed, using ROC curve to make the cut-off value of RLU/CO by hybrid capture Ⅱ （ HC Ⅱ ）. Results ：Among 1221 patients ,there were 667 chronic cervicitis,407 CIN, （ 109 CINⅠ and 298 CIN Ⅱ - Ⅲ ） and 147 cervical carcinoma. The median load of HR-HPV in chronic cervicitis, CIN Ⅰ ,CIN Ⅱ-Ⅲ and cervical carcinoma was 32.58,58.06,103.83 and 173.68 respectively. According to ROC curve, the optimum cut-off of RLU/CO value was 3. 155. Of this point, the sensitivity was 88%, while the specificity was 57%, the Youden index was 0. 466. Conclusion： There is prominent association between viral load of HR-HPV and cervical carcinoma and precancerous lesions. The optimum cut-off of RLU/CO value to predict the lesion worse than CIN Ⅱ is 3. 155.
出处
《现代妇产科进展》
CSCD
北大核心
2008年第10期730-732,共3页
Progress in Obstetrics and Gynecology
基金
浙江省科技厅重大与高发疾病防治技术专项基金资助(No:2006C13080)
