摘要
用对硝基氯苯为原料,经七步反应合成具有季铵盐类结构的8种新标题化合物。经元素分析、核磁共振氢谱、红外吸收光谱和质谱证实。这种类型的2-氧吖丁啶化合物尚未见诸文献。对腊样芽胞杆菌产生的β-内酰胺酶均有不同程度的抑制作用。
A convenient method, starting from 4-nitrochlorobenzene by 7 steps, is reptorted for the synthesis of the 8 novel title compounds. This is the first time to design the oxoazetidinones which consist of the quarternary ammonium salt structure. All the title compounds have been identified via elemental analysis, IR, ~1H NMR and MS. And all of them show inhibitory activity against β-lactamase.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
1990年第12期1212-1215,共4页
Acta Chimica Sinica
