摘要
目的:探讨抗环瓜氨酸肽(抗-CCP)抗体对类风湿关节炎(RA)的临床应用价值,并比较与类风湿因子(RF)之间的相关性以及在临床诊断上的意义。方法:对75例RA患者血清标本和77例对照者的血清标本用酶联免疫吸附试验(ELISA)进行抗-CCP抗体检测,并测定RF,分析RF与抗-CCP抗体的相关性。结果:75例RA患者中,抗-CCP抗体阳性率为56%(42/75),非RA对照组的阳性率为5.2%(4/77),两者有显著差别。抗-CCP抗体对RA诊断的敏感度为56%,特异性为94.8%;阳性和阴性似然比分别为16.08和0.16。抗-CCP抗体和类风湿因子(RF)具有相关性。结论:抗-CCP抗体对RA诊断具有良好的敏感度和特异性,将是协助诊断RA的一个新的实验指标。
Objective：To investigate the diagnostic value of anti-eyelieeitrullinated peptide antibody （ anti- CCP） in the diagnostic of rheumatoid arthritis （RA） and compare the relativity of CCP with Rheumatoid Factor （RF） . Methods： 75 serum samples of patients with Rheumatoid Arthritis , 27 serum samples of other rheumatic diseases and 50 serum samples of normal control subjects were tested for anti-CCP by ELISA, and tested for RF at the same time. Results： 42 （42/75 , 56 %） RA specimen and 4 （4/77,5.2%） control group specimen were found to be anti-CCP positive. There was significant difference between test group and control group. The diagnostic sensitivity of ant-CCP was 56 % with a specificity of 94.8 % in RA. Positive and negative likelihood ratios were 16. 08 and 0.16. Anti-CCP was associated with RF. Conclusion： Anti-CCP presents good specificity and diagnostic sensitivity in rheumatoid arthritis. Anti-CCP might be used as a new valuable index in the diagnosis of RA.
出处
《安徽卫生职业技术学院学报》
2008年第5期34-35,37,共3页
Journal of Anhui Health Vocational & Technical College
关键词
类风湿关节炎
抗环瓜氨酸肽抗体
类风湿因子
rheumatoid arthritis
anti-cycliccitrullinated peptide antibody
Rheumatoid Factor
