摘要
糖尿病并发症与糖代谢多元醇通路激活有关。醛糖还原酶是多元醇代谢通路中的限速酶,醛糖还原酶抑制剂能有效抑制此通路,减慢或改善糖尿病并发症。本文主要概述了微生物来源的醛糖还原酶抑制剂的研究进展。
Diabetic complications is related to the activation of polyalcohol pathway. Aldose reductase is a key rate-limiting enzyme in the pathway, while aldose reductase inhibitors can inhibit the pathway and alleviate the symptoms of diabetic complications. This review mainly gives a brief account of the progress of research on aldose reductase inhibitors from microorganisms.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2008年第11期645-649,共5页
Chinese Journal of Antibiotics
