摘要
目的评价肿瘤放疗对儿童脑室管膜瘤的治疗效果和预后因素。方法2000年至2005年,15例儿童脑室管膜瘤接受术后放疗,男10例,女5例;幕上5例,幕下10例;手术完全切除8例,不完全切除7例;全颅全脊髓放疗5例,全颅加局部放疗4例,局部放疗6例。结果5年生存率为66.7%,死亡5例,局部复发3例,脑脊膜转移2例,5例死亡患儿肿瘤皆位于幕下。年龄、肿瘤位置、病理、是否行全颅全脊髓放疗、性别、手术切除情况对生存率无影响(P均>0.05)。结论肿瘤位于幕下似乎比幕上预后差,幕下脑室管膜瘤是否进行全颅全脊髓全中枢系统的放疗,应根据预后因素来确定。
Objectives To investigate the outcome and prognostic factors of children with primitive intraeranial ependymomas. Methods Between the years of 2000 and 2005, 15 ehildren （10 male and 5 female） under 16 years old with primitive intracranial ependymomas, received postoperative radiotherapy. Tumor located infratentorial in 10 eases and supratentoriel in 5 cases. Complete resection was performed in 8 cases and incomplete resection in 7 cases. All patients were treated with radiotherapy, with eraniospinal axis in 5 cases, whole brain plus local tumor site in 4 cases, local tumor site in 6 cases. Results Five years survival rate was 66.7%. Among five dead patients, three had local recurrence, 2 had meninges metastasis, no patient with supratentorial tumor relapsed locally. Age, tumor site, pathology, the treatment field, gender and extent of surgery had no impact on survival. Conclusions Infratentorial ependymomas seem to have a worse prognosis than supratentorial ones. Irradiation field extent should be correlated to prognostic factors.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2008年第11期936-939,共4页
Journal of Clinical Pediatrics
关键词
室管膜瘤
放疗
预后因素
ependymoma ： radiotherapy
prognostie factors
