摘要
Insoluble breviscapin was chosen as the model drug.Bi-layer osmotic pump technology and gel matrix technology were used to prepare the breviscapin sustained and controlled release preparations.Dissimilarity factors（f1） and similarity factors（f2） were applied as similar judgment index to compare the effects of in vitro conditions on the release behavior of different types of breviscapin sustained and controlled release preparations.The tolerance of in vitro release conditions of bi-layer osmotic pump technology and gel matrix technology were studied.The results showed that in vitro release conditions have a greater impact on the gel matrix sustained release formulations,while have almost no effects on the osmotic pump controlled release formulations.Therefore,osmotic pump controlled release technology is less affected by the drug release environment.And it has a very good application prospect.
Insoluble breviscapin was chosen as the model drug. Bi-layer osmotic pump technology and gel matrix technology were used to prepare the breviseapin sustained and controlled release preparations. Dissimilarity factors （f1） and similarity factors （f2） were applied as similar judgment index to compare the effects of in vitro conditions on the release behavior of different types of breviscapin sustained and controlled release preparations. The tolerance of in vitro release conditions of bi-layer osmotic pump technology and gel matrix technology were studied. The results showed that in vitro release conditions have a greater impact on the gel matrix sustained release formulations, while have almost no effects on the osmotic pump controlled release formulations. Therefore, osmotic pump controlled release technology is less affected by the drug release environment. And it has a very good application prospect.
出处
《药学学报》
CAS
CSCD
北大核心
2008年第11期1161-1164,共4页
Acta Pharmaceutica Sinica
关键词
凝胶骨架技术
渗透泵技术
灯盏花素
释放行为
gel matrix technology
bi-layer osmotic pump technology
breviscapin
release behavior
