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黛力新和帕罗西汀治疗心血管内科焦虑/抑郁患者的对照研究 被引量:3

A control study of Deanxit and Paroxetine in treatment of anxietydepression with cardiovascular symptom
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摘要 目的比较氟哌噻吨美利曲辛(黛力新)和帕罗西汀(赛乐特)治疗心血管内科焦虑/抑郁患者的效果。方法在心血管内科重度焦虑/抑郁患者中随机选择100例,中度和重度患者各50例,随机分为2组,每组50例,每组中度和重度患者各25例。分别采用氟哌噻吨美利曲辛(黛力新)和帕罗西汀(赛乐特)治疗2个月,用临床疗效总评量表(CGI)评定疗效,观察两药对中度和重度焦虑/抑郁患者的疗效。结果100例患者中93例完成疗程,中度焦虑/抑郁总有效率,黛力新组为88.0%,帕罗西汀组为83.0%,两组间差异无统计学意义(P>0.05)。重度焦虑/抑郁总有效率,黛力新组为47.6%,帕罗西汀组为82.6%,两组间差异有统计学意义(P<0.01)。结论对中度焦虑/抑郁患者两种药物疗效相同,对重度焦虑/抑郁患者帕罗西汀好于黛力新。 Objective To investigate the efficaicy of Deanxit and Paroxetine in the patients of anxietydepression, along with cardiovascular symptoms. Methods 100 patients with medium or severe anxietydepression were divided into two groups randomely, who were assessed with Hamilton Rating Scale(HAMA ), each with 25 patients of medium anxietydepression and 25 patients of severe anxietydepression.One group was treated with Deanxit, the other with Paroxetine. The treatment course in both groups was 2 months.Clinical Global Impression (CGI) was used for assessment of therapeutic efficacy. Results 93 cases completed the 2-month treatment while 5 cases dropped out. Compared the Deanxit group, the effective rate in the Paroxetine group was similar(83.0% vs 88.0%) in the patients of medium anxietydepression and was better (82.6% vs 47.6% ) in the patients of severe anxietydepression,respectively. Conclusion In the patients of medium anxietydepression Deanxit possessed efficacy similar to that of Paroxetine. Paroxetine was superior to Deanxit in the patients of severe anxietydepression.
出处 《中国心血管病研究》 CAS 2008年第11期846-847,共2页 Chinese Journal of Cardiovascular Research
关键词 黛力新 帕罗西汀 心血管症状 焦虑/抑郁 Deanxit Paroxetine Cardiovascular sysptoms Anxiety/depression
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