摘要
为了研究左、右心衰竭时血浆肾素（PRA）、血管紧张素（AⅡ）、醛固酮（ALD）及心钠素（ANF）浓度的改变，对36例左心衰竭（心功能11级17例、Ⅲ－Ⅳ级19例）、34例右心衰竭患者及33名正常对照中四者的血浆浓度作了放免测定。结果是左心衰患者血浆PRA、AⅡ、ANF及ALD浓度，右心衰患者血浆PRA、AⅡ、ANF浓度均较正常对照升高（P＜0．01），而右心衰患者ALD血浆浓度下降（P＜0．01），呈现与PRA、AⅡ及ANF的分离现象。左、右心衰竭的患者间及心功能状态不同的患者间相比，四者浓度均有差别。以上四种神经激素参与了心力衰竭的发生、发展过程。
This study evaluated the changes of PRA, A Ⅱ, ALD and ANF concentrations in plasma in heart failure. The concentrations of PRA, A Ⅱ, ALD, ANF in plasma of 36 patients with leftsided heart failure (cardiac functional capacity of 17 cases were Ⅱ, 19 cases were ⅢⅣ), 34 patients with right - sided heart failure and 33 normal controls were detected by PIA.The results show the concentrations of PRA, A Ⅱ, ALD, ANF in plasma of patients with left sided heart failure, the concentrations of PRA, A Ⅱ, ANF of patients with right - sided heart failure all increased than controls (P < 0. 01 ), but ALD concentration of patients with right -sided heart failure decreased apparently (P < 0. 01 )and showed separate phenomenon from PRA, A Ⅱ, ANF. There were also differences between patients of left - and right-sided heart failure and between patients with different condition of cardiac functional capacity. Therefore, the four neurohormones might participate the pathophysiology of heart failure.
出处
《标记免疫分析与临床》
CAS
1997年第4期202-206,共5页
Labeled Immunoassays and Clinical Medicine
