摘要
为了探讨过氧化损伤与糖尿病肾病肾功能损害的关系，本文采用放射免疫分析法（RIA）对43例非胰岛素依赖型糖尿病（NIDDM）患者及28例健康对照者血清中的超过氧化物歧化酶（SOD）水平进行了观察，并将其与尿β2-微球蛋白排泄率（β2-MG）、白蛋白排泄率（Alb）、TammHorsfall糖蛋白排泄率（THP）、总蛋白排泄率（TP）、血尿素氮（BUN）及肌酐（Cr）含量之间的相互关系进行了分析。结果发现：MDDM患者中，不伴肾功能损害者，其SOD水平与健康成人比较无显著性差异（P＞0．05），而伴肾功能损害者，其SOD水平则明显低于健康成人（P＜0．01），且肾功能损害越重者，其SOD水平降低越明显。相关分析发现，伴肾功能损害者的SOD与TP呈显著负相关（n=27，r＝－0．39，P＜0．05）提示NIDDM患者体内SOD代谢失常，抗过氧化能力减弱，致肾小球遭受长期慢性的过氧化损伤可能是糖尿病肾病形成及发展机制中的中心环节。
To investigate the changes of serum superoxide dismutase (SOD) and their re. lation with renal functions in patients with non-insulin-dependent diabetes mellitus (NIDDM),serum SOD concentration was measured by RIA in 43 patients with NIDDM and 28 healthy controls. The relationship between SOD and urinary excretion rates of β2-microglobulin,albumin, Tamm Horsfall protein and total protein was studied. The results showed: 1) serum SOD concentration was significantly decreased in NIDDM patients with renal dysfunction as compared with healthy controls and NIDDM patients without renal dysfunction (P < 0. 01 ); 2) there was no difference in serum SOD concentration between healthy controls and NIDDM patients without renal dysfunction (P >0. 05 ); 3 ) serum SOD concentration was inversely correlated with urinary excretion rate of total protein in NIDDM patients with renal dysfunction (n = 27, r =0. 39, P < 0. 05 ). These findings suggest that the abnormal metablism of SOD and the impairment of anti--oxidate ability may play an important role in the development of diabetic nephropathy in NIDDM patients.
出处
《标记免疫分析与临床》
CAS
1997年第2期71-75,共5页
Labeled Immunoassays and Clinical Medicine
