摘要
目的了解农村地区耐药结核病流行现状以及与耐药结核病发生相关的社会经济学和医疗方面的影响因素,为科学有效地控制结核病提供依据。方法采用拟定的调查表,以当地县结防所登记的肺结核病人为研究对象,收集调查资料;采用酸性罗氏培养法,培养收集阳性标本;采用直接比例法为基础的药物敏感试验,识别目标菌株的耐药种类和耐药类型。使用Epidata3.0软件建立调查表录入数据,SPSS11.0软件进行统计学分析。结果初复治病人分离株均为结核分支杆菌,没有发现其他类型的结核菌。总耐药率为69.60%,同时耐利福平和异烟肼并诊断为耐多药结核病占20.74%。单因素和多因素logistic回归分析均提示:既往治疗史、健康状况、与传染性结核病人接触、个人收入与耐多药的发生有关。结论以往受非正规结核病治疗的影响,新现代结核病控制策略项目地区具有较高的耐多药流行,既往治疗史是耐多药发生的主要指标。经济状况较差的人群和老年病人是耐多药结核病发生的高危人群。
OBJECTIVE Researching the rural region epidemic status about multidrug-resistant tuberculosis as well as the influence factors associated with which respect to the social-economics or medical treatment. To provide scientific advices for effective control of TB. METHODS Adopting the questionnaire working out, taking local county tuberculosis prevention and control register as researching object, and collect the investigates data. Adopting lowenstein-jensen acidity cultivation, cultivating and collecting the specimen; Then adopting the direct comparison of method experiment for the basal medicine sensitive, and identifying the germ bearing medicine cate- gory or type. Besides establishing the investigate from to record into the data with the EPI data 3.0 and analyzing with the SPSSll.0. RESULTS Strains separated from the primary and duplicate treated patients are both Tuberculosis Mycobacterium, not founding any other type of tubercule bacillus.The total resistance rate was 69.6%, resistant both isoniazid and rifampin and diagnosed of Multidrug-resistant tuberculosis accounted for 20.74%.Univariate and multivariate logistic regression analysis both indicate that： history of previous treatment, body mass index （BMI）, contacted with Infectious pulmonary tuberculosis of personal income are related to the multidrug resistant. CONCLUSIONS Influenced by informal formerly treatment for the tuberculosis, the new DOTS project areas have high prevalence of multi-drug resistant. History of previous treatment is the main index leading to multi-drug resistance, people in poor e-conomic conditions and the elderly patients are high-risk group of multi-drug resistant TB.
出处
《中国初级卫生保健》
2008年第11期66-68,共3页
Chinese Primary Health Care
基金
国家自然科学基金资助项目(30371235)。
关键词
耐多药结核病
流行
危险因素
muhidrug-resistant TB, prevalence, risk factor
