摘要
以2-氯磺酰基苯甲酰氯、3-羟基氧杂环丁烷和氨为原料制得2-磺酰氨基苯甲酸-3-氧杂环丁酯(3);选择三乙胺为缚酸剂,氯甲酸苯酯氨化得到N-(4,6-二甲基嘧啶基-2-基)氨基甲酸苯酯(6)。化合物(3)与(6)缩合反应,制备环氧嘧磺隆。反应总收率41%,含量(HPLC)97.4%。
Oxasulfuron was synthesized by the reaction of 2-（oxetan-3-oxycarbonyl）-phenylsulfonamide（3） with phenyl N-（4,6-dimethylpyrimidin-2-yl）carbamate（6）. Using 2-chlorosulfonylbenzoyl chloride, 3-hydroxyoxetane and ammonia as starting materials, compound（3） was conveniently obtained. Meantime, amidation of phenyl chlorocarbonate afforded the intermediate（6）, while triethylamine was selected as a more efficient deacid reagent. The total yield was 41%, and the purity of the target product was up to 97.4%.
出处
《农药》
CAS
北大核心
2008年第11期794-796,共3页
Agrochemicals
