摘要
目的研究异丙酚对体外循环(CPB)致脑损伤的保护作用。方法40例风湿性心脏病瓣膜置换病人随机分为4组:A组,不加异丙酚;B,C,D组分别在CPB期间给予异丙酚2,4,6 mg.kg-1.h-1。分别于麻醉诱导后、CPB结束后1 h及24 h测定血浆S-100β蛋白浓度;麻醉诱导后、CPB结束后24 h及72 h测定血浆神经元性烯醇化酶(NSE)浓度。结果C,D组与A组比较,血浆S-100β蛋白及NSE浓度差别有统计学意义(P<0.01)。结论异丙酚可减轻CPB导致的脑损伤。
Objective To investigate the protective effect of propofol on cerebral injury during cardiopulmonary bypass（CPB） operation. Methods Forty patients undergoing elective cardiac operation for valvular replacement were prospectively randomized into four groups： Group A （unused propofol）, group B（patients received propofol 2mg.kg-1.h-1 during CPB）, Group C（patients received propofol 4 mg.kg-1.h-1 during CPB）, Group D（patients received propofol 6 mg.kg-1.h-1 during CPB）. Jugular venous blood samples were taken for determination of S-100J3 protein content before CPB, 1 hour after CPB , 24 hour after CPB. Jugular venous blood samples were taken for determination of neurone specific enolase（NSE） content before CPB , 24 hour after CPB , 72 hours after CPB. Results All patient＇s S- 100β protein level increased lhour after CPB,and NSE level increased 24 hour after CPB. The level of S- 100β protein and NSE have no significant between groupA and group B （P）0.05）. The levels of S-100β protein and NSE were lower in group C and group D than those in groupA （P〈0.05）. Conclusion CPB leads to cerebral injury. Propofol have the protective effect on cerebral injury during CPB , it correlated with dosage of propofol .
出处
《福建医科大学学报》
2008年第5期455-456,459,共3页
Journal of Fujian Medical University
关键词
二异丙酚
体外循环
脑损伤
propofol
exlracorporeal circulation
brain injurise
