摘要
目的:了解抗精神病药物所致恶性综合征(NMS)的临床特征并探讨NMS发生的影响因素。方法:对某院1例恶性综合征患者病例资料进行分析并复习相关文献资料。结果:抗精神病药物所致NMS男多于女,青壮年居多,传统抗精神病药物与多种抗精神病药物联用、增加剂量过快是产生NMS的危险因素。结论:NMS病情凶险,死亡率高,临床上要认真评估抗精神病药物应用指征,综合考虑患者的个体素质、营养、躯体及精神征状等多种因素来选用抗精神病药物,使用中密切观察病人耐受性,缓慢增加药物剂量,特别是对精神发育迟滞患者、老年患者、有器质性病变及夏季应用吩噻嗪类药物的患者应仔细观察,减少危险因素,有效预防NMS。
Objective ：To understand the clinical characteristics of Neuroleptic malignant syndrome （NMS） caused by using antipsychotic drugs and discuss the impact of factors NMS. Methods：To analyze the clinical data from one case of NMS patients in the hospitai and review the related literature. Results：NMS caused by using antipsychotic drugs male to be more than female, the young adults is in the majority, the risk factors of NMS include ：the traditional anti -God drug being used, and many kind of anti -God drug used together, and increased the drug dosage quickly. Condusion：NMS is a dangerous disease with high death rate, assessing the drug indications carefully in clinical, considering the quality of individual patients, nutrition, physical and mental symptoms, and other factors using drugs, the use of close observation of patients tolerance, slowly increasing drug dose, especially for patients with mental retardation, elderly patients, application of organic disease and summer phenothiazine drugs should be carefully observed to reduce risk factors to be effective in preventing NMS.
出处
《荆门职业技术学院学报》
2008年第9期51-52,共2页
Journal of Jingmen Technical College
关键词
恶性综合征
抗精神病药物
分析
Neuroleptic Malignant Syndrome
antipsyehotie drugs
analysis
