摘要
目的研究叶黄素干预对长期荧屏光暴露者视功能的影响。方法采用双盲随机空白对照研究,将37名22～30岁长期荧屏光暴露者随机分为低剂量组、高剂量组和安慰剂组,分别每天给予6mg叶黄素、12mg叶黄素及安慰剂,连续干预12w。在干预前及干预后12w时,测定血清叶黄素浓度,并检测泪膜破裂时间,临界闪烁融合频率,明视持久度,视觉反应时等视功能指标。结果叶黄素干预后,高剂量组和低剂量组血清叶黄素(μmol/L)水平分别由0.328±0.120和0.356±0.117上升至0.733±0.354和0.607±0.176。高剂量组左眼泪膜破裂时间较干预前显著延长,明视持久度得到显著改善,平均简单反应时较干预前明显缩短;干预后临界闪烁融合频率、辨别反应时和选择反应时无明显变化。结论叶黄素干预对长期荧屏光暴露者泪膜破裂时间、明视持久度及简单反应时有明显改善作用。
Objective To examine the effect of lutein supplementation on visual function in people with long-term display light exposure. Method Thirty-seven persons （age 22-30） with long-term display light exposure were divided into low-dose group, high-dose group, and placebo group involving supplementation with 6 mg lutein/d, 12 mg lutein/d, and placebo for 12 w. The levels of serum lutein and visual function indices such as break-up time （BUT）, critical flicker fusion frequency （CFF）, visuognosis persistence, and reaction time were measured at week 0 and 12. Results After lutein supplementation serum concentrations of high-dose group and low-dose group increased from （0.328±0.120） μmol/L to （0.733±0.354） μmol/L, and from （0.356±0.117） μmol/L to （0.607±0.176） μmol/L respectively. There was significant increase of break up time in left eyes of high-dose group. Visuognosis persistence was significantly improved, and significant decrease of simple reaction time was observed in high-dose group. No statistical change was observed in critical flicker fusion frequency, discriminative reaction time and choice reaction time during the study. Conclusion Visual function indices such as break-up time, visuognosis persistence and simple reaction time in people with long-term display light exposure who received lutein supplements were significantly improved.
出处
《营养学报》
CAS
CSCD
北大核心
2008年第5期438-442,共5页
Acta Nutrimenta Sinica
基金
中国营养学会营养科研基金(No.06094)
