摘要
目的探讨门冬氨酸鸟氨酸(雅博司)联合异甘草酸镁对非酒精性脂肪性肝炎的治疗作用。方法48例非酒精性脂肪性肝炎患者,随机分成治疗组及对照组,各24例。治疗组用雅博司10g/d,1次/d和异甘草酸镁100mg/d,1次/d,静脉滴注;对照组采用异甘草酸镁100mg/d,1次/d,静脉滴注。于治疗后第1及3w观察患者肝功能、血清甘油三酯、胆固醇变化,3w后B超观察肝脏形态变化。结果两组患者于治疗后第1、3w肝功能、血清甘油三酯及胆固醇等方面较治疗前均有明显改善,但治疗组明显优于对照组(P<0.05);治疗组3w后B超肝脏形态改善,要明显优于对照组(P<0.05)。结论雅博司联合异甘草酸镁治疗非酒精性脂肪性肝炎有明显疗效。
Objective To observe the clinical effect of aspartate omithine combined with magnesium isoglycyrrhizinate in chronic non-alcohol fatty hepatitis, Methods 48 patients who suffered from chronic nonalcohol fatty hepatitis were divided into treatment group and control group. The treatment group was treated by aspartate omithine and magnesium isoglycyrrhizinate, and the control group were treated by magnesium isoglycyrrhizinate. After treatment lweek and 3 weeks, the following index such as hepatic functions, triglyceride and cholesterol in serum were observed, liver morphologic change was observed with B ultrasonic wave after treatment 3 weeks. Results After treatment, the patients＇ index of liver function and triglyceride and cholesterol in serum had significantly improved. Nevertheless the treatment group outwent the control group. Conclusion Aspartate omithine combined with agnesium isoglycyrrhizinate has obviously improvement in treating chronic non-alcohol fatty hepatitis.
出处
《药品评价》
CAS
2008年第9期411-412,422,共3页
Drug Evaluation
