摘要
目的探讨脑卒中急性期抑郁患者甲状腺功能的变化。方法对100例急性脑卒中患者进行分组(卒中后无抑郁组66例和卒中后抑郁34例)。收集两组发病第5 d及第14 d 2次空腹血清,采用化学发光法进行甲状腺功能测定,并与40例正常健康体检者(对照组)进行比较。结果第5 d甲状腺功能变化情况:卒中后抑郁组和卒中后无抑郁组比对照组血清游离三碘甲状腺原氨酸(FT3)水平明显下降,而血清游离甲状腺素(FT4)水平显著增高,卒中后抑郁组比卒中后无抑郁组的变化程度更显著;卒中后无抑郁组血清促甲状腺素(TSH)水平比对照组显著增高,但卒中后抑郁组TSH水平升高不明显。第14 d甲状腺功能变化情况:卒中后无抑郁组FT3、FT4、TSH均恢复接近正常,与对照组比较无差异;卒中后抑郁组FT3、FT4虽有恢复但不明显,与对照组比较有显著差异;3组的TSH水平比较均无差异。结论脑卒中患者甲状腺功能发生变化,而卒中后抑郁患者比无抑郁患者FT3、FT4变化更明显,且恢复慢。
Objective To study the change in the thyroid function of the patients with depression after acute stroke. Methods 100 patents suffering from stroke were divided into two groups： The first group was composed of patients without depression （ n = 66） and the second group with depression （ n = 34）. Thyroid function （ VI＇3, FI＇4, TSH） was tested by chemolumineseence method on fifth day and 14th day respectively after stroke and compared with normal control group. Results The change of thyroid function on fifth day： FI3 was significantly decreased but FF4 was obvi- ously elevated in the two groups as compared with the control and the changes were more obvious in the second group than in the first group; TSH was greatly increased in the first group as compared with the control, whereas it had no sig- nificant difference from the control in the second group. The changes of thyroid function on the 14th day： the levels of FF3, FF4 and TSH were almost within the normal ranges in the first group and had no difference from the control; but Fr3 and FT4 were still abnormal in the second group as compared with the control. TSH was not significantly different between the three groups. Conclusion The thyroid function changes after stroke and the changes of FF3 and VF4 are more significant in the patients with post stroke depression than those without depression and recover slowly.
出处
《黑龙江医学》
2008年第10期729-731,共3页
Heilongjiang Medical Journal
关键词
脑血管意外
抑郁症
甲状腺素
神经分泌系统
Cerebrovascular accident
Depression
Thyroxine
Neurosecretery
systems
