摘要
目的:研究幽门螺杆菌(HP)感染与白介素-8(IL-8)、白介素-10(IL-10)和胃泌素(GAS)的关系。方法:108例患者均经13C-尿素呼气实验和血清学检测HP,并于晨起空腹在胃镜检查前后取静脉血2mL,3 000rpm离心10分钟,分离血清,测定血清中GAS、IL-8、IL-10的含量。结果:HP阳性组血清IL-8、IL-10、GAS含量分别为51.49±9.41pg/mL、312.84±47.91pg/mL、10.34±7.24ng/mL。HP阴性组血清IL-8、IL-10、GAS含量分别为37.44±9.05pg/mL、356.39±51.89pg/mL和5.12±3.51ng/L。HP阳性组血清IL-8、GAS含量分别高于阴性组(P<0.01),IL-10含量低于HP阴性组(P<0.01)。HP阳性组血清IL-8与GAS间呈正相关(r=0.382,P<0.01),IL-10与GAS间呈负相关(r=-0.202,P<0.05)。结论:HP感染的慢性胃炎和消化性溃疡患者IL-8、IL-10、GAS含量变化与HP感染有关,HP感染胃肠黏膜产生的炎症损伤与IL-8有关,血清IL-10对炎症有抑制作用。
Objective ：To study the relation of helicobaeter pylori （HP） infection to IL- 8, IL- 10 and GAS. Methods： HP was determined in 108 patients by ^13C- urea expiration test and serology and their venous blood was taken（2mL for each） before or after gastroscopy examination, with stomach empty and serum separated by 10 minutes centrifugalization to determine the contents of GAS, IL -8 AND il - 10 in the serum. Results： IL -8,IL - 10 and GAS content in the serum of positive group wasrespeetively 51.49±9.41 pg/mL,312.84±47.91pg/mL and 10.34±7.24ng/mL. IL - 8, IL - 10 and GAS content in the serum of HB negative group was respectively 37.44±9.05 pg/mL,356.39±51.89pg/mL and 5.12±3.51 ng/mL. IL - 8 and GAS content in the serum of HP positive group was higher than that in the negative group（ P 〈0.01 ）. IL - 10 content is lower than that in the HP negative group（ P 〈0.01 ）. HP positive group blood serum IL- 8 and GAS presents the positive correlation （ r = 0. 382, P 〈 0. 01 ）, IL- 10 and GAS assumes negative correlation（ r = -0.202, P 〈0.05 ）. Conclusion： Changes in IL- 8, IL- 10 and GAS of the chronic gastritis and digestion ulcer patients with HP infection are correlated to HP infection. HP - induced inflammatory damages to gastroenteric mucusa are related to blood serum IL - 8 and blood serum IL - 10 has inhibitory action on inflammation.
出处
《包头医学院学报》
CAS
2008年第5期454-455,共2页
Journal of Baotou Medical College
