摘要
目的:探讨血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、血管内皮生长因子(vascular endothelial growth factor,VEGF)水平与糖尿病视网膜病变的关系。方法:将108例糖尿病患者分为糖尿病视网膜病变组(DR,60例)、非糖尿病视网膜病变组(NDR,48例),DR组又分为非增生性糖尿病视网膜病变亚组(NPDR,34例)、增生性糖尿病视网膜病变亚组(PDR,26例)。健康对照组40例。采用ELISA法检测血清TNF-α和VEGF水平,分析对比。结果:糖尿病患者血清TNF-α和VEGF水平与健康对照组比较,有显著性差异(P<0.01)。DR组血清TNF-α和VEGF水平显著高于NDR组(P<0.01);PDR组血清TNF-α和VEGF水平显著高于NPDR组(P<0.05)。结论:血清TNF-α和VEGF可能参与了DR的发生、发展,血清TNF-α、VEGF水平可反映DR病情严重程度。
AIM： To explore the relation among tumor necrosis factor-α（TNF-α） ,vascular endothelial growth factor（VEGF） and diabetic retinopathy （DR）.
METHODS： Totally 108 diabetics were divided into diabetic retinopathy （DR） group （60 cases）, non-diabetic retinopathy （NDR） group （48 cases）, diabetic retinopathy ＋ non-proliferative diabetic retinopathy （DR ＋ NPDR） group （34 cases） and proliferative diabetic retinopathy （PDR） group （26 cases）. Other 40 normal persons were as controls. The level of serum TNF-α and VEGF were measured by ELISA and the results were compared and analyzed.
RESULTS. The level of serum TNF-α and VEGF were higher significantly in patients with diabetes than those in controls （P〈0.01）, in DR group than those in NDR group （P〈0.01）, in PDR group than those in NPDR group （P〈 0.O5）.
CONCLUSION：The serum TNF-α and VEGF may participate in the occurrence and development of DR, and be related to the seriousness of DR.
出处
《国际眼科杂志》
CAS
2008年第10期2032-2033,共2页
International Eye Science
