摘要
目的评价不同体温对兔不同剂量顺式阿曲库铵肌松效应的影响。方法健康成年新西兰大白兔72只，体重2．0～2．2kg，雌雄各半，随机分为低体温组（L组）、常温组（N组）和高体温组（H组），每组24只，各组直肠温度依次为34．5、38．5和41．8℃，各组随机分为4个亚组，T1-4组、N1-4组和H1-4组，每组6只。各亚组分别于直肠温度稳定20min后静脉注射顺式阿曲库铵0．33、0．66、0．99和1．32mg／kg，于改变动物体温前5min、给药前2min、给药后5、10、30、60、90min时监测平均动脉压（MAP）、心率（HR）及直肠温度，记录肌松起效时间、从注药毕到T1恢复至基础值5％、25％和95％的时间及恢复指数。结果不同体温下相同剂量组间比较：与N组比较，H组肌松起效时间、从注药毕到，T1恢复至基础值5％、25％和95％的时间及恢复指数缩短，L组延长（P〈0．05或0．01）；相同体温下不同剂量组间比较：随顺式阿曲库铵剂量增加，各组肌松起效时间缩短、从注药毕到T1恢复至基础值5％、25％和95％的时间延长（P〈0．01）；剂量与体温因素的交互作用对起效时间的影响差异有统计学意义（P〈0．01）；相同剂量不同体温下MAP、HR比较：与N组比较，H组各时点MAP降低、HR升高，L组各时点MAP、HR升高（P〈0．05或0．01）。结论体温升高时顺式阿曲库铵的肌松效应降低，体温降低时顺式阿曲库铵的肌松效应升高；相同体温下顺式阿曲库铵（0．33～1．32mg／kg）的肌松效应呈剂量依赖性；两因素间存在交互作用。
Objective To investigate the effects of different body temperatures on the neuromuscular block induced by different doses of cisatracurium in rabbits. Methods Seventy-two healthy New Zealand white rabbits of both sexes weighing 2.0-2.2 kg were randomly divided into 3 groups （n = 24 each）： hypothermia group （L）, normothermia group （N） and hyperthermia group （H）. The rectal temperature was set at 34.5℃, 38.5℃ and 41.8℃ in group L, N and H respectively. Each group was further divided into 4 subgroups （ n = 6 each） receiving intravenous cisatracurium 0.33, 0.66, 0.99 and 1.32 mg/kg respectively after rectal temperature was stabilized for 20 min. The animals were anesthetized with iv 20% urethane 1 g/kg, tracheostomized and mechanically ventilated （ VT 12 ml/kg, RR 60 bpm, I ： E = 1 ： 2 ; FiO2 100 % ）. TOF was monitored. The onset time, the duration of action （from the end of cisatracurium injection to the recovery of T1 to 5% , 25% and 95% of control height） and recovery, index （recovery of T1 from 25% to 75% of control height） were recorded. MAP, HR and rectal temperature were recorded at 5 min before alteration of the body temperature, at 2 min before and 5, 10, 30, 60 and 90 min after administration of cisatracurium. Results （ 1 ） With the same dose of cisatracurium the onset time and duration of action were significantly shorter in group H, longer in group L and recovery from N-M block faster in group H, slower in group L as compared with group N. （2） At the same body temperature the onset time was significantly shortened and the duration of action and recovery were significantly prolonged as the dose of cisatracurium increased. （3） There was significant difference in the effect of interaction between different doses of cisatracurium and different temperatures on the onset time. （4） With the same dose of cisatracurium MAP was significantly decreased in group H, increased in group L, while HR was significantly increased in group H, decreased in group L. C
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2008年第9期800-803,共4页
Chinese Journal of Anesthesiology
关键词
阿曲库铵
体温
神经肌肉阻滞
Atracurium
Body temperature
Neuromuscular blockade
