摘要
目的:探讨多巴胺D4受体DRD4基因多态性同强迫症(OCD)的关系。方法:采用PCR-AmFLP技术测定105例OCD患者和100例健康对照者的DRD4基因48bp可变数目重复序列的多态性。结果:OCD组与对照组间等位基因频数分布差异显著(P<0.05);其中患者组在4倍48bp重复序列纯合子的分布上明显低于对照组(P<0.05)。结论:DRD4基因48bp可变数目重复序列的多态性可能与强迫症的发病有关。
Objective： To investigate the relationship between polymorphism of dopamine receptor D4 （DRD4 ） gene and obsessive-compulsive disorder （OCD）. Method： 105 OCD patients and 100 healthy controls were enrolled. All subjects were genotyped directly by polymerase chain reaction amplification fragment length polymorphism techniques. Results：There were significant differences of allele frequencies of DRD4 between OCD patients and controls（ P 〈 0.05 ） , a lower frequency of the homozygote 4R in OCD patients compared to normal controls （ P 〈 0.05 ）. Conclusion ： The polymorphism of DRD4 receptor gene may be associated with OCD.
出处
《临床精神医学杂志》
2008年第5期310-311,共2页
Journal of Clinical Psychiatry
关键词
强迫症
基因
多巴胺D受体
多态性
obsessive-compulsive disorder
gene
dopamine receptor D4
polymorphism
