摘要
建立顶空毛细管气相色谱法测定盐酸利多卡因中的有机溶剂残留量.用HP-FFAP毛细管气相色谱柱,顶空进样法,FID检测器,以正丙醇为内标进行测定.二氯甲烷、丙酮的线性范围分别为1.0～600.0mg/L(r=0.9998),2.0～800.0mg/L(r=0.9995);二氯甲烷、丙酮的平均回收率分别为99.6%,99.2%;RSD分别为2.3%,1.3%(n=5).本方法简单、准确、灵敏度高、重现性好,适用于盐酸利多卡因中有机溶剂残留量的测定.
To develop the headspace gas chromatography method for the determination of residual organic solvents in lidocaini hydrochloridum,the samples were injected into HP-FFAP capillary column by headspace sampler and analysed with FID detector using n-propanol as the internal standard.The linear ranges of dichloromethane and acetone were 1.0～600.0 mg/L （r=0.999 8）,2.0～800.0 mg/L （r = 0.999 5） respectively. The recoveries were 99.6% and 99.2% with RSD 2.3% and 1.3%（n = 5） respectively. The method is simple ,accurate and sensitive with good reproducibility.It can be used for the determination of the residual organic solvents in lidocaini hydroehloridum.
出处
《海南师范大学学报（自然科学版）》
CAS
2008年第3期300-302,311,共4页
Journal of Hainan Normal University（Natural Science）
关键词
盐酸利多卡因
顶空进样法
毛细管气相色谱法
有机溶剂残留量
lidocaini hydrochloridum
headspace injection
capillary gas chromatography
residual organic solvents
