摘要
目的探讨HIE新生儿血浆肾上腺髓质素(ADM)和血清肿瘤坏死因子-α(TNF-α)水平的变化及其与窒息后脑损伤的关系。方法按病情程度将50例HIE分为轻度HIE组(20例)、中度HIE组(16例)和重度HIE组(14例);同期选择10例健康足月新生儿作对照(健康对照组)。采用放射免疫分析法测定不同程度HIE患儿和健康对照组新生儿血浆ADM和血清TNF-α、神经特异性烯醇化酶(NSE)水平。结果1.与健康对照组相比,HIE组患儿血浆ADM和血清TNF-α、NSE水平明显升高,差异有显著统计学意义(Pa<0.01);轻度HIE组、中度HIE组和重度HIE组患儿血浆ADM和血清TNF-α、NSE水平依次升高,两两比较差异有显著统计学意义(Pa<0.01)。2.HIE组患儿血浆ADM、血清TNF-α和NSE水平均呈显著正相关(r=0.85,0.89,0.83 Pa<0.01)。3.HIE预后差患儿血浆ADM、血清TNF-α和NSE水平高于预后好者(Pa<0.01)。结论ADM和TNF-α均参与新生儿HIE的病理生理过程,其可作为判断HIE病情严重程度和预后的早期标志物。
Objective To explore the changes of plasma adrenomedullin （ADM） and tumor necrosis factor - alpha （TNF - α） in neonates with HIE and their relationships with post - asphyxial brain injury. Methods According to illness severity,50 cases with HIE were divided into mild HIE group（20 cases） ,moderate HIE group（ 16 cases） ,serious HIE group（ 14 cases） ,and 10 health neonates were regarded as healthy control grnup. The levels of plasma ADM and serum TNF - α, neuron - specific enolase（NSE） in 50 different degree HIE newborns and 10 healthy newborns were measured by radioimmunoassay. Results 1. Compared with healthy control group,the levels of plasma ADM and serum TNF - α, NSE in HIE newborns were obviously increased,the differences were significant（ Pa 〈 0.01 ）. The levels of plasma ADM and serum TNF-α, NSE were increased by turns in miht HIE, nmderate HIE and serious HIE groups,the differences were significant（ Pa 〈 0.01 ）. 2. There were significant positive correlation relationship between ADM, serum TNF - α and NSE in HIE newborns（ r = 0.85,0.89, 0. 83 P, 〈 0.01 ）. 3. The levels of plasma ADM and serum TNF - α, NSE in the bad prognosis group were higher than those of the good prognosis group（ Pa 〈0.01 ）. Conclusions Both ADM and TNF - α can participate in the process of pathn - physiology in neonate with HIE,they may be regarded as early index in evalulating the severity and clinical prognosis of HIE.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2008年第20期1613-1614,共2页
Journal of Applied Clinical Pediatrics
基金
四川省学术和技术带头人培养资金项目资助(4200325)
