摘要
为探讨氧化修饰低密度脂蛋白（Ox－LDL）与冠状动脉狭窄程度的关系。对68例行冠状动脉造影，其中冠心病组48例，非冠心病组20例，测定其血浆Ox－LDL水平及血清脂质、脂蛋白等指标，各检测指标与冠状动脉病变严重度积分（CSS）行直线相关分析及多因素逐步回归分析。结果：冠心病组血浆Ox－LDL水平显著高于非冠心病组，且随着冠状动脉病变支数的增加，血浆Ox-LDL水平逐渐增高；直线相关分析显示血浆Ox－LDL水平与CSS呈显著正相关，多因素逐步回归分析示血浆Ox－LDL水平对冠状动脉病变严重度的预测价值优于目前临床上常用的血脂、脂蛋白及载脂蛋白。结论：血浆Ox－LDL水平对冠状动脉病变具有一定的预测价值。
Oxidation of low density lipoprotein (Ox-LDL) plays an important role in the pathogenesis of atherosclerosis. In order to ascertain whether the plasma level of Ox-LDL is related to the extent of coronary stenosis, we studied the plasma level of Ox-LDL by enzyme-linked immunosorbent assay in 68 cases who had undergone diagnostic coronary angiography. The subjects were divided into two groups: those who had >50% luminal stenosis in one or more coronary arteries and those who had <50% stenosis. Plasma Ox-LDL levels were 0. 72 ± 0. 21 mg/L in 48 cases with coronary artery disease (CAD), significantly higher than 0. 34±0. 15 mg/L in 20 normal subjects (NS) (P<0.001). The plasma levels of Ox-LDL were the highest in the group of triple vessle disease (0. 82±0.49 mg/L) and higher in doub1e vessle group (0.69±0. 26 mg/L)than in NS (all P±0.001). A significant positive correlation was found between the plasma OxLDL level and the coronary severity score (CSS) which was assessed by coronary angiography (r=-0. 790 4, P<0.001). Multipe steped regression analysis showed that the diagnostic value of Ox-LDL on CSS was better than other lipid items. The results suggest that high Ox-LDL is related to the extent of coronary stenosis and may lead to the development and progression of CAD. Also the raise of Ox-LDL level possess certain predictive value for the diagnosis of CAD.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1997年第6期323-326,共4页
Journal of Clinical Cardiology
基金
山东省卫生厅科研基金
关键词
冠状动脉疾病
脂蛋白
狭窄
OX-LDL
氧化修饰
Coronary artery disease Oxidized low density lipoprotein Coronary severity score
