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心力衰竭后心房肿胀激活性氯通道的变化 被引量:1

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摘要 研究心力衰竭(简称心衰)对心房肌肿胀激活性氯通道(ICl,swell)基因表达及其通道蛋白表达水平的影响。新西兰白兔20只随机分为2组:对照组10只(其中假手术5只),心衰组10只。心衰组结扎冠状动脉左前降支,假手术兔只穿线不结扎。8周后,取左心耳组织,应用RT-PCR和Western blot技术检测左心耳氯通道基因表达和蛋白水平的变化。与对照组相比,心衰组左心耳ICl,swell基因表达明显上升,ICl,swell蛋白含量也升高(P均<0.05)。兔心衰后心房肌的ICl,swell基因表达及其蛋白水平均明显升高。
出处 《中国心脏起搏与心电生理杂志》 2008年第5期461-462,共2页 Chinese Journal of Cardiac Pacing and Electrophysiology
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参考文献7

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二级参考文献6

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