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口腔颌面部恶性肿瘤病人可溶性白介素2受体的检测 被引量:3

Determination of Serum sIL-2R Levels of Patients With Oral-Maxillofacial Malignant Tumours
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摘要 本试验采用ELLSA法检测了60例口腔颌面部恶性肿瘤病人,21例口腔颌面部良性肿瘤病人,30例正常人的sIL-2R水平。结果:恶性肿瘤病人sIL-ZR水平较良性肿瘤病人较正常人水平明显升高(P<0.001),良性肿瘤病人与正常人间无差异(P>0.05),且sIL-2R水平与病理分级及临床分期有关。sIL-2R作为监视机体免疫状态的一种指标可帮助诊断分析、病情监测及预后评估。 Serum sIL-2R levels of 60 cases of patients with oralmaxillofacial malignant tumors(OMFMTs), 21 cases of patients with oral-maxillofacia1 benign tumors (OMFBTs) and 30 cases ofnormal groups were detected with sandwich ELISA. The results show as follows: (1)The sIL-2R levelsof patients with OMFMTs were significantly higer than those of patients with OMFBTs and also thoseof normal groups. (2)There is no difference of sIL-2R levels between patients with OMFBTs and nor-mal groups. (3)The sIL-2R levels of patients with OMFMTs seem to be considerably correlated withclassification and stage of OMFMTs. The sIL-2R as an indicator reflecting the immunological state inhuman body may help diagnosis and appraise prognosis.
出处 《临床口腔医学杂志》 1997年第4期210-212,共3页 Journal of Clinical Stomatology
关键词 白介素2受体 恶性肿瘤 口腔颌面部 Soluble interleukin-2 receptors, Malignant tumor, Oral-maxillofacial region
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  • 1Rubin LA, Kurman CC, Fritz ME, et al. Soluble interleukin-2 receptors are released from activated human lymphoid cells in vitro. J Immunol, 1985,135 : 3172-3176. 被引量:1
  • 2Baran D, Moreau JL, Theze J,et al. New radioimmunoassay for detection of freeIL-2 receptor in supernatants of murine helper and cytotoxic T-cell lines. Ann Inst Pasteum/Immunol, 1986,17 : 123-131. 被引量:1
  • 3Tsukamoto S, Ishikawa S,yamauchi A, et al. Serum soluble interleukin-2 receptor levels in patients with renal cell carcinoma: a comparison of values before and after surgery. Hinyokika Kiyo, 2000, 46(10) : 695-699. 被引量:1
  • 4Gebauer G, Rieger M, Jager W, et al. Prognostic relevance of soluble interleukin-2 receptors in patients with ovarian tumors. Anticancer Res, 1999,19(4) : 2509-2511. 被引量:1
  • 5Mantovani G, Maccio A, Lai P, et al. Results of a doseintense phase 1 study of a combination chemotherapy regimen with cisplatin and epidoxorubicin including medroxyprogesterone acetate and recombinant interleukin-2 in patients with inoperable primary lung cancer. J Immunother, 2000,23(2) : 267-274. 被引量:1
  • 6Rubin LA,Kurman CC,Fritz ME,et al. Soluble interleukin-2 receptors are released from activated human lymphoid cells in vitro. J Immunol,1985,135:3172-3176. 被引量:1
  • 7Baran D,Moreau JL ,Theze J ,et al. New radioimmunoassay for detection of free IL-2 receptor in supernatants of murine helper and cytotoxic T-cell lines. Ann Inst Pasteum Immunol, 1986,17D: 123-131. 被引量:1
  • 8Tsukamoto S,Ishikawa S ,yamauchi A ,et al. Serum soluble interleukin-2 receptor levels in patients with renal cell carcinoma:a comparison of values before and after surgery. Hinyokika Kiyo,2000,46(10):695-699. 被引量:1
  • 9Gebauer G,Rieger M,Jager W,et al. Prognostic relevance of soluble interleukin-2 receptors in patients with ovarian tumors. Anticancer Res, 1999,19(4) :2509-2511. 被引量:1
  • 10Brivio F, Lissoni P,Mancini D,et al. Effection of antitumor surgery on soluble interleukin-2 receptors serum levels. Am J Surg, 1990,61 : 466-473. 被引量:1

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